Morphometric study of rat jejunum enterocyte after L-Arginine and L-NAME prescription

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MOVASSAGHI SHABNAM; SHARIFI ZAHRA NADIA; NOORI MUGAHI SEYED MOHAMMAD HOSSEIN

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Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2022 | Volume:32 | Issue:2 Page(s): 132-138

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Title

Morphometric study of rat jejunum enterocyte after L-Arginine and L-NAME prescription

Author(s)

MOVASSAGHI SHABNAM | SHARIFI ZAHRA NADIA | NOORI MUGAHI SEYED MOHAMMAD HOSSEIN

Keywords

Nitric oxide

L-Arginine

L-NAME

Epithelial cell

Jejunum

Abstract

Background: Nitric oxide (NO) is a very important signaling molecule which acts as a regulator of many physiological processes in many tissues including Epithelial cell of gastrointestinal tract. In this study we investigated the effects of L-Arginine as a NO progenitor and L-NAME as a NO inhibitor on Epithelial cell number and height of Jejunum in female rats. Materials and methods: 40 female rats were divided into 5 groups, containing 8 rats in each group. Except the control group, the other groups received normal saline (2 ml/kg), L-Arginine (200mg/kg), L-NAME (20mg/kg) and a mixture of two substances for L-Arginine & L-NAME group intraperitoneally for 3 days. 2 weeks later after anesthesia with ether, Jejunum was expelled out and after tissue processing and staining with H&E method, the changes were assessed via light microscopy. Cell number and height were evaluated using Image Tools3 Microsoft. Statistical analysis was made by One-Way ANOVA followed by Tukey post hoc test to evaluate the statistical significance between different groups. A value of p< 0. 05 was considered statistically significant. Results: There was a significant increase in the cell number and height of jejunal epithelium in L-Arginine group (P<0. 05). Whereas no significant difference was observed between L-NAME, L-Arginine +L-NAME and control, Normal Saline groups. Conclusion: L-Arginine can result in proliferation of Jejunum Epithelial cells whereas L-NAME has no effect on these cells.

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APA: Copy

MOVASSAGHI, SHABNAM, & SHARIFI, ZAHRA NADIA. (2022). Morphometric study of rat jejunum enterocyte after L-Arginine and L-NAME prescription. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 32(2 ), 132-138. SID. https://sid.ir/paper/1000376/en

Vancouver: Copy

MOVASSAGHI SHABNAM, SHARIFI ZAHRA NADIA. Morphometric study of rat jejunum enterocyte after L-Arginine and L-NAME prescription. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2022;32(2 ):132-138. Available from: https://sid.ir/paper/1000376/en

IEEE: Copy

SHABNAM MOVASSAGHI, and ZAHRA NADIA SHARIFI, “Morphometric study of rat jejunum enterocyte after L-Arginine and L-NAME prescription,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 32, no. 2 , pp. 132–138, 2022, [Online]. Available: https://sid.ir/paper/1000376/en

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