Evaluation of the Interactive Effect of Warfarin Administration with Continuous and Interval Training on Levels of Cardiac MGP Protein and Renal Function Indexes in Rats of Myocardial Infarction Model: An Experimental Study

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Abbasi Tooran; BANAEIFAR ABDOLALI; ARSHADI SAJAD; KAZEMZADEH YASER

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Journal Paper

Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2022 | Volume:21 | Issue:2 Page(s): 165-186

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Title

Evaluation of the Interactive Effect of Warfarin Administration with Continuous and Interval Training on Levels of Cardiac MGP Protein and Renal Function Indexes in Rats of Myocardial Infarction Model: An Experimental Study

Author(s)

Abbasi Tooran | BANAEIFAR ABDOLALI | ARSHADI SAJAD | KAZEMZADEH YASER | Issue Writer Certificate

Keywords

Exercise

Warfarin

Kidney

Myocardial Inferaction

Abstract

Background and Objectives: Heart-Kidney disorders affect on each other. Exercise training can control heart and Kidney cell damages. The aim of this study is to determine the effect of Exercise training and Warfarin administration on cardiac matrix Gla protein (MGP) and indices of renal injury in rats of myocardial infarction model. Materials and Methods: In this experimental study, 42 male Sprague-Dawley rats (180-220 grams) were randomly divided into 7 groups of healthy control, myocardial infarction or ischemia (ISC), ISC+interval training, ISC+ continuous training, ISC+Warfarin, ISC+interval training+Warfarin, and ISC+continuous training+Warfarin. The duration of interval and continuous training was eight weeks, five sessions per week. Induction of myocardial infarction was performed with subcutaneous injection of isoproterenol. Cardiac MGP was measured by western blotting, creatinine and blood urea nitrogen (BUN) by photometric method, and cystatin C by Turbidimetry. Glomerular filtration rate (GFR) was calculated according to cystatin C consideration. Independent t-test and twofactor analysis of variance were used to analyze the data. Results: Myocardial infraction decreased MGP protein (p=0. 001), increased creatinine (p=0. 001), BUN (p=0. 002), and cystatin C (p=0. 001), and decreased GFR (p=0. 001) compared to the control group. The main effect of Exercise type on all variables, the main effect of Warfarin on MGP and BUN, and also interaction of Warfarin and Exercise type on MGP were significant. Conclusion: Exercise training had a better effect on cardiac MGP and control of renal injury markers compared to Warfarin. Therefore, in heart and Kidney diseases with Warfarin therapy, Exercise training should be carefully planned.

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APA: Copy

Abbasi, Tooran, BANAEIFAR, ABDOLALI, ARSHADI, SAJAD, & KAZEMZADEH, YASER. (2022). Evaluation of the Interactive Effect of Warfarin Administration with Continuous and Interval Training on Levels of Cardiac MGP Protein and Renal Function Indexes in Rats of Myocardial Infarction Model: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 21(2 ), 165-186. SID. https://sid.ir/paper/1002750/en

Vancouver: Copy

Abbasi Tooran, BANAEIFAR ABDOLALI, ARSHADI SAJAD, KAZEMZADEH YASER. Evaluation of the Interactive Effect of Warfarin Administration with Continuous and Interval Training on Levels of Cardiac MGP Protein and Renal Function Indexes in Rats of Myocardial Infarction Model: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2022;21(2 ):165-186. Available from: https://sid.ir/paper/1002750/en

IEEE: Copy

Tooran Abbasi, ABDOLALI BANAEIFAR, SAJAD ARSHADI, and YASER KAZEMZADEH, “Evaluation of the Interactive Effect of Warfarin Administration with Continuous and Interval Training on Levels of Cardiac MGP Protein and Renal Function Indexes in Rats of Myocardial Infarction Model: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 21, no. 2 , pp. 165–186, 2022, [Online]. Available: https://sid.ir/paper/1002750/en

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