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Information Journal Paper

Title

Synergistic Effect of 4 Weeks of Endurance Training with Probiotic Supplementation on the Expression of Atrogin-1 and Murf-1 Genes in the Soleus Muscle of Diabetic Rats

Pages

  198-209

Abstract

 Background: One of the most common problems in diabetic patients is Muscle atrophy. Therefore, the present study aimed to investigate the synergistic effect of endurance training with probiotic supplementation on Atrogin-1 and MuRF-1 genes gene expression in the soleus muscle of diabetic rats. Methods: In this study, 32 male Wistar rats were randomly divided into one normal control (NC) and four diabetic groups: diabetic control (DC), diabetic supplement (SDC), diabetic training (TD), and diabetic supplement training (STD). The training protocol was performed with 60 to 65% of maximum speed reached five days a week for four weeks. At the same time, rats took two grams of probiotic dissolved in 30 ml of water daily. Expression of Atrogin-1 and MuRF-1 genes was measured by the qReal-Time PCR method. Data were analyzed by two-way analysis of variance at the significant level of P≤, 0. 05. Results: Atrogin-1 gene expression was significantly reduced in TD (P=0. 001) and STD (P=0. 000) groups compared to DC group. There was a significant difference between TD and STD groups in the expression of the Atrogin-1 gene (P=0. 028). MuRF-1 gene expression was significantly reduced in TD (P=0. 04) and STD (P=0. 01) groups compared to DC. But there was no significant difference between TD and STD groups in MuRF-1 gene expression (P=0. 36). Conclusion: It seems that performing the Aerobic exercise with probiotic supplementation is more effective in reducing the expression of the Atrogin-1 gene than any of these interventions alone. However, Aerobic exercise with probiotic supplementation does not have a synergistic effect on reducing MuRF-1 gene expression in the soleus muscle of diabetic rats compared to Aerobic exercise alone.

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    APA: Copy

    DELFAN, MARYAM, & Bouriaei, Tina. (2021). Synergistic Effect of 4 Weeks of Endurance Training with Probiotic Supplementation on the Expression of Atrogin-1 and Murf-1 Genes in the Soleus Muscle of Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 21(4 ), 198-209. SID. https://sid.ir/paper/1008746/en

    Vancouver: Copy

    DELFAN MARYAM, Bouriaei Tina. Synergistic Effect of 4 Weeks of Endurance Training with Probiotic Supplementation on the Expression of Atrogin-1 and Murf-1 Genes in the Soleus Muscle of Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;21(4 ):198-209. Available from: https://sid.ir/paper/1008746/en

    IEEE: Copy

    MARYAM DELFAN, and Tina Bouriaei, “Synergistic Effect of 4 Weeks of Endurance Training with Probiotic Supplementation on the Expression of Atrogin-1 and Murf-1 Genes in the Soleus Muscle of Diabetic Rats,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 21, no. 4 , pp. 198–209, 2021, [Online]. Available: https://sid.ir/paper/1008746/en

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