Evaluation of the Gene Expression of Tumor Necrotic Factor Alpha and Interlukine-6 in Rat Model of Diabetes Type 2 Treated with Silver Nanoparticles Synthetized by Galega Officinalis Extract

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Saeidi Elaheh; MAHMOUDI FARIBA; Noorizadeh Ezzat; MAHMOUDI FARZANEH

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2021 | Volume:21 | Issue:4 Page(s): 250-263

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Title

Evaluation of the Gene Expression of Tumor Necrotic Factor Alpha and Interlukine-6 in Rat Model of Diabetes Type 2 Treated with Silver Nanoparticles Synthetized by Galega Officinalis Extract

Author(s)

Saeidi Elaheh | MAHMOUDI FARIBA | Noorizadeh Ezzat | MAHMOUDI FARZANEH | Issue Writer Certificate

Keywords

Galega officinalis

silver nanoparticle

liver enzymes

TNF-α

IL-6

Abstract

Background: Hypoglycaemic effects of Galega officinalis and silver nanoparticles are established. In the present study, the effects of silver nanoparticles synthetized by Galega officinalis extract were investigated on gene expression of TNF-α, , IL-6 and serum levels of liver enzymes in diabetes type 2. Methods: In the present study 20 male Wistar rats in 4 group(n= 5 in each group) weighing 180-200 gr were used. Control or nikotinamid and stroptozotosin induced diabetic rats receieved intraperitoneal injection of saline or 2/5mg/Kg silver nanoparticles synthetized by Galega officinalis extract or chemichal method for 14 days respectively. One day after the last injections, serum samples and adipose tissue were collected. Mean serum concentration of glucose, urea, creatinine, alanine amino transferase(ALT), and aspartate amino transferase(AST) were determined by spectrophotometry. Mean relative gene expression of TNF-α,and IL-6 were determined by method of real time PCR. Results: Mean serum levels of ALT and AST enzymes, glucose, urea significantly decreased in diabetic rats receiving chemichal or green silver naoparticles compared to diabetic group. Mean relative gene expression of TNF-α,and IL-6 significantly decreased in diabetic rats receiving chemichal or green silver naoparticles compared to diabetic ones. Conclusion: Both chemical and green synthetized silver nanoparticles may prevent hepatocyes damages and they may improve insulin resistance in diabetes type 2 partly via decresing pro-inflammatory factors.

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APA: Copy

Saeidi, Elaheh, MAHMOUDI, FARIBA, Noorizadeh, Ezzat, & MAHMOUDI, FARZANEH. (2021). Evaluation of the Gene Expression of Tumor Necrotic Factor Alpha and Interlukine-6 in Rat Model of Diabetes Type 2 Treated with Silver Nanoparticles Synthetized by Galega Officinalis Extract. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 21(4 ), 250-263. SID. https://sid.ir/paper/1008799/en

Vancouver: Copy

Saeidi Elaheh, MAHMOUDI FARIBA, Noorizadeh Ezzat, MAHMOUDI FARZANEH. Evaluation of the Gene Expression of Tumor Necrotic Factor Alpha and Interlukine-6 in Rat Model of Diabetes Type 2 Treated with Silver Nanoparticles Synthetized by Galega Officinalis Extract. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;21(4 ):250-263. Available from: https://sid.ir/paper/1008799/en

IEEE: Copy

Elaheh Saeidi, FARIBA MAHMOUDI, Ezzat Noorizadeh, and FARZANEH MAHMOUDI, “Evaluation of the Gene Expression of Tumor Necrotic Factor Alpha and Interlukine-6 in Rat Model of Diabetes Type 2 Treated with Silver Nanoparticles Synthetized by Galega Officinalis Extract,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 21, no. 4 , pp. 250–263, 2021, [Online]. Available: https://sid.ir/paper/1008799/en

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