Effects of Empagliflozin on Sexual Function, Testicular Histology and Biochemical Parameters in Young and Middle-Aged Diabetic Rats of Type2

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Dana Parisa; HAYATI RODBARI NASIM; YAGHMAEI PARICHEHREH; HAJEBRAHIMI ZAHRA

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2021 | Volume:21 | Issue:4 Page(s): 210-228

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Information Journal Paper

Title

Effects of Empagliflozin on Sexual Function, Testicular Histology and Biochemical Parameters in Young and Middle-Aged Diabetic Rats of Type2

Author(s)

Dana Parisa | HAYATI RODBARI NASIM | YAGHMAEI PARICHEHREH | HAJEBRAHIMI ZAHRA | Issue Writer Certificate

Keywords

Empagliflozin

sex hormones

histology

testis

diabetic of type2

Abstract

Background: Empagliflozin, selective glucose-sodium inhibitor of the latest drugs in the treatment of type 2 diabetes. Diabetes induced hypogonadism disrupts sexual function. There is a direct relationship between reducing blood glucose and reduced libido. In this project, the anti-diabetic drug Empagliflozin in addition to treatment has been studied, in terms of effect on sexual function. Methods: Type 2 diabetes with injection of 60 mg/kg streptozotocin per body weight was create intraperitoneally. The primary diabetes was treated with two doses of 10 and 25 mg/kg Empagliflozin per body weight. Sexual hormones, biochemical parameters and lipid profile were measured. Evaluation of Sperm parameters and morphological studies were performed on testicular tissue, pancreas and epididymis. Data were analyzed by one-way ANOVA in SPSS software version 22 and P˂, 0. 05 was considered as a significant level. Results: Empagliflozin significantly increases the quality, survival and natural state of sperm head and tail. Empagliflozin reduces weight in diabetic rats. Empagliflozin Without increasing hyperglycemia by reducing blood glucose affects steroidogenesis, maintains fertility strength in testicles, and increases the level of sex hormones. Empagliflozin significantly increases insulin secretion. Empagliflozin maintains and integrity of pancreatic beta cells. Empagliflozin has no effect on lipid profile. Conclusion: Empagliflozin in addition positive effects on the treatment of diabetes in the early stage improves sexual function in adult rats.

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APA: Copy

Dana, Parisa, HAYATI RODBARI, NASIM, YAGHMAEI, PARICHEHREH, & HAJEBRAHIMI, ZAHRA. (2021). Effects of Empagliflozin on Sexual Function, Testicular Histology and Biochemical Parameters in Young and Middle-Aged Diabetic Rats of Type2. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 21(4 ), 210-228. SID. https://sid.ir/paper/1009117/en

Vancouver: Copy

Dana Parisa, HAYATI RODBARI NASIM, YAGHMAEI PARICHEHREH, HAJEBRAHIMI ZAHRA. Effects of Empagliflozin on Sexual Function, Testicular Histology and Biochemical Parameters in Young and Middle-Aged Diabetic Rats of Type2. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;21(4 ):210-228. Available from: https://sid.ir/paper/1009117/en

IEEE: Copy

Parisa Dana, NASIM HAYATI RODBARI, PARICHEHREH YAGHMAEI, and ZAHRA HAJEBRAHIMI, “Effects of Empagliflozin on Sexual Function, Testicular Histology and Biochemical Parameters in Young and Middle-Aged Diabetic Rats of Type2,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 21, no. 4 , pp. 210–228, 2021, [Online]. Available: https://sid.ir/paper/1009117/en

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