The Effect of Eight-Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats

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Torabi Palat Kaleh Ghasem; Sadeghi Abbas; Maleki Mohammad Javad; ABDI AHMAD

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2022 | Volume:22 | Issue:3 Page(s): 133-144

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Information Journal Paper

Title

The Effect of Eight-Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats

Author(s)

Torabi Palat Kaleh Ghasem | Sadeghi Abbas | Maleki Mohammad Javad | ABDI AHMAD | Issue Writer Certificate

Keywords

Exercise

Angiostatic

Angiogenic

Diabetes

Abstract

Background: Diabetes can increase cardiovascular disease by altering the equilibrium between Angiogenic stimulants and inhibitors of angiogenesis. In this study, we investigated the effect of High-Intensity Interval Training (HIIT) on angiostatin and focal adhesion kinase (FAK-1) in left ventricle cardiomyocytes in diabetic rats. Methods: In this experimental study, 24 male Wistar rats were randomly divided into three equal groups (n=8): Control-Normal (C), Diabetes (D), and Diabetes-training (D+T). Diabetes was induced by the injection of streptozotocin in male rats. The Training group has performed a HIIT program on a motor-driven treadmill for eight weeks. At the end of eight weeks--heart tissue samples were collected. Data were analyzed using ANOVA and Tukey post hoc at P<0. 05. Results: The results showed that induction of Diabetes increased the expression of angiostatin (P=0. 006), and serum glucose (P=0. 001) and decreased FAK-1 (P=0. 001). HIIT significantly reduced the level of angiostatin (P=0. 006) and glucose (P=0. 001) in diabetic rats. There was also a significant increase in FAK-1 in the D+T group (P=0. 001). Conclusion: HIIT decreased the protein expression of angiostatin and glucose and increased FAK-1 in cardiomyocytes. HIIT seems to reduce the vascular complications of Diabetes in rats by altering these parameters that affect angiogenesis and blood glucose.

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APA: Copy

Torabi Palat Kaleh, Ghasem, Sadeghi, Abbas, Maleki, Mohammad Javad, & ABDI, AHMAD. (2022). The Effect of Eight-Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 22(3 ), 133-144. SID. https://sid.ir/paper/1009255/en

Vancouver: Copy

Torabi Palat Kaleh Ghasem, Sadeghi Abbas, Maleki Mohammad Javad, ABDI AHMAD. The Effect of Eight-Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2022;22(3 ):133-144. Available from: https://sid.ir/paper/1009255/en

IEEE: Copy

Ghasem Torabi Palat Kaleh, Abbas Sadeghi, Mohammad Javad Maleki, and AHMAD ABDI, “The Effect of Eight-Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 22, no. 3 , pp. 133–144, 2022, [Online]. Available: https://sid.ir/paper/1009255/en

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