The Effect of Endurance Training on Angiostatin and Enos Gene Expression of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ghorbanalipour Ali Asghar; MOTAMEDI PEZHMAN; RAJABI HAMID; KARAMI HADI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2019 | Volume:21 | Issue:7 (136) Page(s): 112-122

Download Full-Text

Persian Verion

View:

445

Download:

Cites:

Information Journal Paper

Title

The Effect of Endurance Training on Angiostatin and Enos Gene Expression of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats

Author(s)

Ghorbanalipour Ali Asghar | MOTAMEDI PEZHMAN | RAJABI HAMID | KARAMI HADI | Issue Writer Certificate

Keywords

AngiostatinQ1

Endurance trainingQ1

eNOSQ1

Abstract

Background and Aim: The eNOS gene that is responsible for the production of nitric oxide and Angiostatin is an inhibitor of angiogenesis. The aim of present study was to investigate the effect of Endurance training on Angiostatin and eNOS gene expression of cardiac tissue in type 2 diabetic male wistar rats. Materials and Methods: In an experimental study, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance training (DET, n=12), Diabetic Control (DC, n=12) and Healthy Control (HC, n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The Endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 15 minutes in 1st week and reached to 27 m/min for 60 min/day in 9th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of Angiostatin and eNOS were examined by Real-Time PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0. 05. Ethical Considerations: This study was approved in Research Ethics Committee of Arak university of medical sciences with the code IR. ARAKMU. REC. 1394. 329. Findings: The gene expression of Angiostatin and eNOS of DC group showed significant increase compared to HC group (p =0. 000). The Endurance training induced significant decrease in the gene expression of Angiostatin and eNOS compared to DC group (p =0. 000). Conclusion: It appears that gene expression of Angiostatin and eNOS of diabetic cardiac tissue are affected by positive effect of Endurance training.

Cites

No record.

References

Imbalance of angiogenesis in diabetic complications: the mechanisms

Cite

APA: Copy

Ghorbanalipour, Ali Asghar, MOTAMEDI, PEZHMAN, RAJABI, HAMID, & KARAMI, HADI. (2019). The Effect of Endurance Training on Angiostatin and Enos Gene Expression of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(7 (136) ), 112-122. SID. https://sid.ir/paper/68981/en

Vancouver: Copy

Ghorbanalipour Ali Asghar, MOTAMEDI PEZHMAN, RAJABI HAMID, KARAMI HADI. The Effect of Endurance Training on Angiostatin and Enos Gene Expression of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;21(7 (136) ):112-122. Available from: https://sid.ir/paper/68981/en

IEEE: Copy

Ali Asghar Ghorbanalipour, PEZHMAN MOTAMEDI, HAMID RAJABI, and HADI KARAMI, “The Effect of Endurance Training on Angiostatin and Enos Gene Expression of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 7 (136) , pp. 112–122, 2019, [Online]. Available: https://sid.ir/paper/68981/en

Related Journal Papers