Can use NKX2-1 Gene as Indicator of Differentiation of Papillary Thyroid Carcinoma?

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MOKHTARI MOHAMMAD; JAVADIRAD SEYED MORTEZA; KOLAHDOUZAN MOHSEN

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Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2022 | Volume:23 | Issue:4 (80) Page(s): 33-39

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Information Journal Paper

Title

Can use NKX2-1 Gene as Indicator of Differentiation of Papillary Thyroid Carcinoma?

Author(s)

MOKHTARI MOHAMMAD | JAVADIRAD SEYED MORTEZA | KOLAHDOUZAN MOHSEN | Issue Writer Certificate

Keywords

Papillary Thyroid Carcinoma

Cell Differentiation

NKX2-1

Abstract

Background and Objective: Thyroid cancer is a common cancer of the endocrine system, and knowing the etiology can be effective in its treating. On the other hand, the FNA technique is not accurate enough, so finding a biomarker for thyroid cancer is of importance. This study was done to evaluate the NKX2-1 gene as indicator of differentiation of Papillary Thyroid Carcinoma (PTC). Methods: In this case-control study, 17 fresh PTC tissue samples and 20 adjacent-healthy tissues were collected during thyroidectomy in Isfahan, Iran. RNA extraction was followed by cDNA synthesis. The expression of the NKX2-1 gene was performed using specific primers (exon-junction and intron spanning) using the RT-qPCR method. Results: An examination of the quality and quantity of extracted RNAs showed that they were intact and suitable for making cDNA. Examination of the melting curve showed a specific amplification of the NKX2-1 gene. The difference in expression of the NKX2-1 gene between PTC and healthy-adjacent tissues was 0. 947. Conclusion: No difference in the expression of the NKX2-1 gene between the healthy tissue adjacent to the tumor and the tissue of the PTC tumor indicates that the PTC tumors were differentiated.

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APA: Copy

MOKHTARI, MOHAMMAD, JAVADIRAD, SEYED MORTEZA, & KOLAHDOUZAN, MOHSEN. (2022). Can use NKX2-1 Gene as Indicator of Differentiation of Papillary Thyroid Carcinoma?. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 23(4 (80) ), 33-39. SID. https://sid.ir/paper/1012944/en

Vancouver: Copy

MOKHTARI MOHAMMAD, JAVADIRAD SEYED MORTEZA, KOLAHDOUZAN MOHSEN. Can use NKX2-1 Gene as Indicator of Differentiation of Papillary Thyroid Carcinoma?. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;23(4 (80) ):33-39. Available from: https://sid.ir/paper/1012944/en

IEEE: Copy

MOHAMMAD MOKHTARI, SEYED MORTEZA JAVADIRAD, and MOHSEN KOLAHDOUZAN, “Can use NKX2-1 Gene as Indicator of Differentiation of Papillary Thyroid Carcinoma?,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 4 (80) , pp. 33–39, 2022, [Online]. Available: https://sid.ir/paper/1012944/en

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