Protein Sequence Analysis of E1 Surface Glycoprotein of Hepatitis C Virus

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ZAREH KHOSHCHEHREH R.; BAMDAD T.; Arab S.S.; BEHDANI M.; BIGLAR M.

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Journal Paper

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Journal: Iranian Journal of Virology Year:2022 | Volume:16 | Issue:1 Page(s): 7-15

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Title

Protein Sequence Analysis of E1 Surface Glycoprotein of Hepatitis C Virus

Author(s)

Keywords

E1 envelope glycoprotein

Mutation

Epitope

Neutralization

Vaccine design

Abstract

Background and Aims: Hepatitis C Virus infects more than 170 million people globally despite highly effective direct acting antiviral drugs that greatly improved treatment. The Hepatitis C virus envelope glycoproteins E1 and E2 are the major target to induce immune responses. Since, the different aspects of E1 such as its function and structure are still discussed and require further study, in current study critical regions of E1 were evaluated. Materials and Methods: Mutation diversity in these areas was determined using strains that were available in online databanks and authentic software. Furthermore, RT-PCR for E1 was done on HCV-1a positive samples and the sequences were analyzed. The percentage of substitutions, desired and stable residues for Mutation in each position were indicated. Results: The integrated results exhibited bNAb Epitope (residues 313-328) which is the most conserved Epitope in E1 glycoprotein sequence among all genotypes of HCV. Conclusion: These kinds of studies may shed light on identification more binding sites of virus and broadly cross-Neutralization of antibodies. Moreover, it may facilitate the modeling of peptides to new antiviral design or boosting the immune response in multi-Epitope vaccine studies.

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In silico rational design of a novel tetra-epitope tetanus vaccine with complete population coverage using developed immunoinformatics and surface epitope mapping approaches

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APA: Copy

ZAREH KHOSHCHEHREH, R., BAMDAD, T., Arab, S.S., BEHDANI, M., & BIGLAR, M.. (2022). Protein Sequence Analysis of E1 Surface Glycoprotein of Hepatitis C Virus. IRANIAN JOURNAL OF VIROLOGY, 16(1), 7-15. SID. https://sid.ir/paper/1014966/en

Vancouver: Copy

ZAREH KHOSHCHEHREH R., BAMDAD T., Arab S.S., BEHDANI M., BIGLAR M.. Protein Sequence Analysis of E1 Surface Glycoprotein of Hepatitis C Virus. IRANIAN JOURNAL OF VIROLOGY[Internet]. 2022;16(1):7-15. Available from: https://sid.ir/paper/1014966/en

IEEE: Copy

R. ZAREH KHOSHCHEHREH, T. BAMDAD, S.S. Arab, M. BEHDANI, and M. BIGLAR, “Protein Sequence Analysis of E1 Surface Glycoprotein of Hepatitis C Virus,” IRANIAN JOURNAL OF VIROLOGY, vol. 16, no. 1, pp. 7–15, 2022, [Online]. Available: https://sid.ir/paper/1014966/en

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