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Information Journal Paper

Title

The effect of spraying the suspension containing adipose derived mesenchymal stem cells on diabetic wound healing and collagen synthesis in skin tissue in an animal model

Pages

  34-44

Abstract

 Background and Objective: Although many studies have been performed concerning the effects of adipose-derived Mesenchymal stem cells on wound healing, the repairing effects of these cells are still controversial. In this context, the present study investigated the effect of Spraying the adipose-derived Mesenchymal stem cells suspension on Diabetic wound healing and skin tissue Collagen synthesis in an animal model. Materials and Methods: In this experimental study, abdominal Adipose tissue was obtained from patients referred for abdominoplasty. Mesenchymal cells were isolated from Adipose tissue and identified by micoscoic examination and flow cytometry. Streptozotocin was used to induce diabetes in 10 male Wistar rats. Wounds with a diameter of 0. 8 cm were created by a biopsy punch in the back of diabetic rats. Animals were divided into two groups: control (untreated) and treated with mesenchymal cell. After treatment, wound healing was assessed by photographic methods on days 7, 14 and 21 and the Collagen synthesis was evaluated using Mason’, s trichrome method. Results: Observational data showed that the wound healing rate was higher in the treatment group than control group. 21 days after treatment, the density of Collagen fibers, the formation of tissue vessels and the Collagen fibers arrangement had higher quality in the treatment group than the control group. Conclusion: Spraying the adipose-derived Mesenchymal stem cells in Diabetic wound area can increase the Collagen synthesis in the wound area and accelerate the healing of the Diabetic wound. According to which, the use of these cells can be considered in cell therapy of wounds.

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    Cite

    APA: Copy

    Zare, Sona, AHMADI, EBRAHIM, & Ghiaee, Pouria. (2022). The effect of spraying the suspension containing adipose derived mesenchymal stem cells on diabetic wound healing and collagen synthesis in skin tissue in an animal model. DANESHVAR MEDICINE, 29(157 ), 34-44. SID. https://sid.ir/paper/1015216/en

    Vancouver: Copy

    Zare Sona, AHMADI EBRAHIM, Ghiaee Pouria. The effect of spraying the suspension containing adipose derived mesenchymal stem cells on diabetic wound healing and collagen synthesis in skin tissue in an animal model. DANESHVAR MEDICINE[Internet]. 2022;29(157 ):34-44. Available from: https://sid.ir/paper/1015216/en

    IEEE: Copy

    Sona Zare, EBRAHIM AHMADI, and Pouria Ghiaee, “The effect of spraying the suspension containing adipose derived mesenchymal stem cells on diabetic wound healing and collagen synthesis in skin tissue in an animal model,” DANESHVAR MEDICINE, vol. 29, no. 157 , pp. 34–44, 2022, [Online]. Available: https://sid.ir/paper/1015216/en

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