Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis

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Dugeroglu Harun; Yilmaz Mustafa

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Journal: Disease and Diagnosis Year:2021 | Volume:10 | Issue:1 Page(s): 29-35

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Title

Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis

Author(s)

Dugeroglu Harun | Yilmaz Mustafa | Issue Writer Certificate

Keywords

Non-alcohol-related liver cirrhosis

Child-Turcotte-Pugh score

D-dimer

Fibrinogen

D-dimer/fibrinogen ratio

Abstract

Background: Liver cirrhosis is one of the most significant causes of death in many regions worldwide. This study aimed to assess the correlation of hemostatic and endocrine parameters with Child-Turcotte-Pugh (CTP) scoring in patients with non-alcoholic liver cirrhosis. Materials and Methods: This study included 59 patients monitored for non-alcoholic liver cirrhosis in a gastroenterology clinic from January 2018 to February 2019. The subjects were grouped according to the CTP scores, and their adrenocorticotropic hormone (ACTH), cortisol, dehydroepiandrosterone sulfate (DHEA-SO4), progesterone, growth hormone (GH), insulin-like growth factor-1 (IGF-1), GH/IGF-1 ratio, Fibrinogen, D-dimer, and D-dimer/fibrinogen ratio were measured. Results: According to CTP scoring, 20. 3% of patients were CTP-A (n=12), 35. 6% were CTP-B (n=21), and 44. 1% were CTP-C (n=26). There were statistically significant differences for IGF-1, DHEA-SO4, and GH/IGF-1 ratios between CTP-A and CTP-B groups (P = 0. 002, P = 0. 043, P = 0. 038, respectively). Additionally, there were statistically significant differences between the CTP-B and CTP-C groups for D-dimer and GH values (P = 0. 024, P = 0. 006, respectively). There were statistically significant differences for D-dimer, GH, IGF-1, and D-dimer/fibrinogen ratio between the CTP-A and CTP-C groups (P < 0. 001, P = 0. 016, P = 0. 002, P = 0. 031, respectively). Conclusion: Severe hemostatic and endocrine complications develop in patients with liver cirrhosis due to non-alcoholic causes. Additionally, it seems that using D-dimer and D-dimer/fibrinogen ratio, along with Fibrinogen level, can be beneficial in showing liver damage in these patients.

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APA: Copy

Dugeroglu, Harun, & Yilmaz, Mustafa. (2021). Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis. DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE), 10(1), 29-35. SID. https://sid.ir/paper/1018103/en

Vancouver: Copy

Dugeroglu Harun, Yilmaz Mustafa. Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis. DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE)[Internet]. 2021;10(1):29-35. Available from: https://sid.ir/paper/1018103/en

IEEE: Copy

Harun Dugeroglu, and Mustafa Yilmaz, “Evaluating the Correlation of Hemostatic and Endocrine Parameters with Child-Turcotte-Pugh Scoring in Patients with Non-Alcoholic Liver Cirrhosis,” DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE), vol. 10, no. 1, pp. 29–35, 2021, [Online]. Available: https://sid.ir/paper/1018103/en

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