مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

51
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

116
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Comparing the Histopathological Effects of Selenium Nanoparticles and Selenium Nanocomposites in Rat Models

Pages

  75-81

Abstract

 Background: Selenium Nanoparticles (Se NPs) and Selenium nanocomposites (Se NCs) have different biological effects. The current study aimed to compare the effects of newly synthesized Se NPs and Se NCs on biochemical and histopathological parameters of rats. The synthesized Se NPs were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDAX), and scanning electron microscopy (SEM) techniques. Materials and Methods: Adult male Wistar rats were divided into four equal groups to examine the biological effects of Se NPs. Control rats received saline intraperitoneally while experimental rats were received four-week intraperitoneal injections of Se powder, Se NPs, and Se NCs at the dose of (0. 4 mg/kg). After four weeks, serum was obtained by the conventional methods, and then rats were sacrificed to separate liver, kidney, and testis tissues for histopathological examinations. Results: The intraperitoneal injection of Se powder caused significant elevations in serum liver enzyme levels, serum blood urea nitrogen (BUN) lipid peroxidation, and serum creatinine levels (P < 0. 05). The histopathological investigations showed necrosis and fatty change in liver. kidney sections showed cytoplasmic vacuolation and hyaline casts, and the testis sections showed degeneration of seminiferous tubules. Se NPs intraperitoneal injections at a dose of 0. 4 mg/kg caused no significant effects on liver enzymes, malondialdehyde (MDA) content, and histopathological changes while significantly increased serum BUN and creatinine levels (P < 0. 05). The group treated with Se NCs showed normal biochemical and histopathological parameters (P < 0. 05). Conclusion: The current study proved the Toxicity of Se powder,however, nano-formulations of Se showed fewer side effects.

Multimedia

  • No record.

    • Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    HAJINEZHAD, MOHAMMAD REZA, JAMSHIDIAN, ABBAS, Abdollahi, Motahareh, & SAMZADEH KERMANI, ALIREZA. (2021). Comparing the Histopathological Effects of Selenium Nanoparticles and Selenium Nanocomposites in Rat Models. DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE), 10(2), 75-81. SID. https://sid.ir/paper/1018190/en

    Vancouver: Copy

    HAJINEZHAD MOHAMMAD REZA, JAMSHIDIAN ABBAS, Abdollahi Motahareh, SAMZADEH KERMANI ALIREZA. Comparing the Histopathological Effects of Selenium Nanoparticles and Selenium Nanocomposites in Rat Models. DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE)[Internet]. 2021;10(2):75-81. Available from: https://sid.ir/paper/1018190/en

    IEEE: Copy

    MOHAMMAD REZA HAJINEZHAD, ABBAS JAMSHIDIAN, Motahareh Abdollahi, and ALIREZA SAMZADEH KERMANI, “Comparing the Histopathological Effects of Selenium Nanoparticles and Selenium Nanocomposites in Rat Models,” DISEASE AND DIAGNOSIS (INTERNATIONAL ELECTRONIC JOURNAL OF MEDICINE), vol. 10, no. 2, pp. 75–81, 2021, [Online]. Available: https://sid.ir/paper/1018190/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button