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Information Journal Paper

Title

The Protective Effect of Chicoric Acid on the Mancozeb-induced Male Reproductive Damage in Mice

Pages

  0-0

Abstract

 Background and Aim: This study aimed to evaluate the protective effect of Chicoric acid (CA) on Mancozeb-induced male reproductive damage in Mice. Methods: 65 NMRI male Mice were randomly divided into 7 groups (n=8),1: control group, 2: MZB–, induced toxicity 3: MZB+ atropine (0. 25 mg/kg daily), groups 4, 5, and 6: MZB+25, 50 and 100 mg/kg of CA respectively. 7: CA (100 mg). The Mice were sacrificed thirty-five days later and blood and testis samples were obtained. Testosterone levels, Sperm parameters, protamine deficiency, and Sperm chromatin dispersion (SCD) were used to evaluate the reproductive system function. Results: The Sperm count and Sperm viability decreased in the MZB-intoxicated group,the Sperm DNA fragmentation and protamine deficiency increased in this group. Head and neck deformity decreased in MZB+ CA groups (p<0. 05). In MZB+ CA groups, the Sperm motility type A, and B increased than the MZB group, abnormal Sperm morphology within 100 mg/kg CA groups was less than 50 and 25 mg/kg. The groups pretreated with CA showed a significant increase in Leydig cells. Conclusion: The results revealed that Chicoric acid has a protective effect on testis tissue damage induced by MZB. So, this is a promising therapeutic choice for the treatment of male infertility.

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    APA: Copy

    FOROUZANDEH, HOSSEIN, AHMADI, IRAJ, & AKBARI, HAKIMEH. (2021). The Protective Effect of Chicoric Acid on the Mancozeb-induced Male Reproductive Damage in Mice. ARCHIVES OF MEDICAL LABORATORY SCIENCES, 7(1), 0-0. SID. https://sid.ir/paper/1019714/en

    Vancouver: Copy

    FOROUZANDEH HOSSEIN, AHMADI IRAJ, AKBARI HAKIMEH. The Protective Effect of Chicoric Acid on the Mancozeb-induced Male Reproductive Damage in Mice. ARCHIVES OF MEDICAL LABORATORY SCIENCES[Internet]. 2021;7(1):0-0. Available from: https://sid.ir/paper/1019714/en

    IEEE: Copy

    HOSSEIN FOROUZANDEH, IRAJ AHMADI, and HAKIMEH AKBARI, “The Protective Effect of Chicoric Acid on the Mancozeb-induced Male Reproductive Damage in Mice,” ARCHIVES OF MEDICAL LABORATORY SCIENCES, vol. 7, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/1019714/en

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