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Title

The Expression Level of CCDC26 and FOXCUT Genes in Acute Lymphoblastic Leukemia

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  0-0

Abstract

 Background and Aim: Acute Lymphoblastic Leukemia (ALL) is a malignant disease of lymphoid progenitor cells affecting both children and adults. Long Non-Coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), reported modulating the initiation or progression of diverse cancers. However, the role of CCDC26 and FOXCUT Long Non-Coding RNAs in ALL has been unknown. In this study, we explored the expression of FOXCUT and CCDC26 lncRNAs in Acute Lymphoblastic Leukemia cell lines. Methods: Acute T lymphoblastic leukemia cell lines, RPMI 8402, Jurkat, B lymphoblastic leukemia, Daudi, and Ramos cell lines were used. After culturing the cells, RNA extraction and cDNA synthesis were performed. The realtime PCR technique was then used to study the expression of CCDC26, FOXCUT, C-Kit, and FOXC1 genes. Result: We found a significant increase of CCDC26 expression in RPMI 8402 (p <0. 0001) and Ramos (p <0. 05) cell lines compared to the control, while decreased expression of these genes was observed in Jurkat and Daudi cell lines. Furthermore, FOXCUT gene had a significant increase in expression in all cell lines compared to the control (p <0. 01 in Daudi and RPMI 8402 cell lines) (p <0. 001 in Jurkat and Ramos cell lines). Conclusion: Our results demonstrated that CCDC26 and FOXCUT genes can play a regulatory role in Acute Lymphoblastic Leukemia and may serve as a potential diagnostic biomarker and therapeutic target of Acute Lymphoblastic Leukemia.

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    APA: Copy

    Barati, Samaneh, MOUSAVI, SEYED HADI, Motallebzadeh-Khanmiri, Jamal, & Khani Eshratabadi, Mohammad. (2021). The Expression Level of CCDC26 and FOXCUT Genes in Acute Lymphoblastic Leukemia. ARCHIVES OF MEDICAL LABORATORY SCIENCES, 7(1), 0-0. SID. https://sid.ir/paper/1019716/en

    Vancouver: Copy

    Barati Samaneh, MOUSAVI SEYED HADI, Motallebzadeh-Khanmiri Jamal, Khani Eshratabadi Mohammad. The Expression Level of CCDC26 and FOXCUT Genes in Acute Lymphoblastic Leukemia. ARCHIVES OF MEDICAL LABORATORY SCIENCES[Internet]. 2021;7(1):0-0. Available from: https://sid.ir/paper/1019716/en

    IEEE: Copy

    Samaneh Barati, SEYED HADI MOUSAVI, Jamal Motallebzadeh-Khanmiri, and Mohammad Khani Eshratabadi, “The Expression Level of CCDC26 and FOXCUT Genes in Acute Lymphoblastic Leukemia,” ARCHIVES OF MEDICAL LABORATORY SCIENCES, vol. 7, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/1019716/en

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