The Frequency of Integrons and OXA Genes in Uropathogenic Isolates of Klebsiella pneumoniae

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Pourbaghi Elmira; HOSSEINI DOUST REZA; RAHBAR MOHAMMAD; RAHNAMAYE FARZAMI MARJAN

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Journal: Archives of Medical Laboratory Sciences Year:2021 | Volume:7 | Issue:1 Page(s): 0-0

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Title

The Frequency of Integrons and OXA Genes in Uropathogenic Isolates of Klebsiella pneumoniae

Author(s)

Pourbaghi Elmira | HOSSEINI DOUST REZA | RAHBAR MOHAMMAD | RAHNAMAYE FARZAMI MARJAN | Issue Writer Certificate

Keywords

Klebsiella pneumoniae

Urinary Tract Infection

Integron

Antimicrobial Susceptibility

Carbapenem

Abstract

Background and Aim: One of the most critical concerns in Klebsiella pneumoniae isolated from nosocomial infections is antibiotic resistance due to transferable resistance genes. This study aims to investigate the relationship and role of Integrons in the transport of OXA-type genes in the production of Carbapenem-resistant isolates. Methods: In this study, 270 isolates of K. pneumoniae were isolated from patients with Urinary Tract Infection symptoms hospitalized at Milad hospital of Tehran during 2017-2018. The biochemical methods confirmed K. pneumoniae isolates. Also, Antimicrobial Susceptibility testing was performed using an E-test method. Carbapenemresistant isolates were confirmed using an automated Antimicrobial Susceptibility testing system (Phenix BD USA). The presence of OXA genes, Integron, and its class were determined by PCR method. Results: According to our findings, the most effective antibiotics against uropathogenic K. pneumoniae isolates were piperacillin-tazobactam and meropenem, respectively. Out of the 270 isolates, 27 (10%) were detected as Carbapenemresistant K. pneumoniae isolates. Moreover, 47. 2%, 40. 1%, 39. 2%, and 36. 4% of K. pneumoniae isolates were resistant to ceftriaxone, ceftazidime, trimethoprim-sulfamethoxazole, and amoxicillin/clavulanate, respectively. A significant proportion of isolates had class I Integron. Meaningful differences in OXA-51, 58, and 24 genes were found in Carbapenem-resistant and Carbapenem-susceptible K. pneumoniae isolates. No significant relationship was observed between class 1 and 2 Integrons and other studied gene determinants of antimicrobial resistance. Conclusion: According to the observed results, OXA-23, OXA-24, OXA-58, and OXA-51-like groups were the most prevalent genes in Carbapenem-resistant K. pneumoniae isolates, respectively. Also, 97. 9% of Carbapenem-susceptible K. pneumoniae isolates had class 1 Integron.

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APA: Copy

Pourbaghi, Elmira, HOSSEINI DOUST, REZA, RAHBAR, MOHAMMAD, & RAHNAMAYE FARZAMI, MARJAN. (2021). The Frequency of Integrons and OXA Genes in Uropathogenic Isolates of Klebsiella pneumoniae. ARCHIVES OF MEDICAL LABORATORY SCIENCES, 7(1), 0-0. SID. https://sid.ir/paper/1020181/en

Vancouver: Copy

Pourbaghi Elmira, HOSSEINI DOUST REZA, RAHBAR MOHAMMAD, RAHNAMAYE FARZAMI MARJAN. The Frequency of Integrons and OXA Genes in Uropathogenic Isolates of Klebsiella pneumoniae. ARCHIVES OF MEDICAL LABORATORY SCIENCES[Internet]. 2021;7(1):0-0. Available from: https://sid.ir/paper/1020181/en

IEEE: Copy

Elmira Pourbaghi, REZA HOSSEINI DOUST, MOHAMMAD RAHBAR, and MARJAN RAHNAMAYE FARZAMI, “The Frequency of Integrons and OXA Genes in Uropathogenic Isolates of Klebsiella pneumoniae,” ARCHIVES OF MEDICAL LABORATORY SCIENCES, vol. 7, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/1020181/en

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