The Association between the Level of Glycosylated Hemoglobin and the Immunogenicity of the Rubella Vaccination

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HAGHIGHI MEHRDAD; GOUDARZI MEHDI; SISTANIZAD MOHAMMAD; Pourheidar Elham

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Journal Paper

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Journal: NOVELTY IN BIOMEDICINE Year:2022 | Volume:10 | Issue:1 Page(s): 9-11

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Title

The Association between the Level of Glycosylated Hemoglobin and the Immunogenicity of the Rubella Vaccination

Author(s)

HAGHIGHI MEHRDAD | GOUDARZI MEHDI | SISTANIZAD MOHAMMAD | Pourheidar Elham | Issue Writer Certificate

Keywords

Diabetes Mellitus

Rubella

Antibodies

Glycosylated hemoglobin

Abstract

Background: Diabetes mellitus (DM) can influence various aspects of the immune system that may alter the immune response to vaccines. Data about altering the immune response to the rubella vaccine in the presence of diabetes are not enough. We aimed to evaluate the association between the level of glycosylated hemoglobin (HbA1C) and the immunogenicity of the rubella vaccination. Materials and Methods: This cross-sectional retrospective study was conducted on the medical records of women who were tested to pre-pregnancy to check their antibody levels against rubella and had plasma levels of HbA1C. Results: During 3 years, 112 women with anti-Rubella IgG data were finally analyzed. The mean age±, SD of participants was 32. 10±, 4. 87. According to the data, we detected no correlation between the plasma levels of HbA1C and IgG levels against rubella (Correlation Coefficient 0. 219, p = 0. 020). Conclusion: We revealed no correlation between the plasma levels of HbA1C and impaired immunogenicity of the rubella vaccination. We recommended a large-scale controlled clinical trial to evaluate the IgG levels against rubella in patients with high plasma levels of HbA1C compared to the control group.

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APA: Copy

HAGHIGHI, MEHRDAD, GOUDARZI, MEHDI, SISTANIZAD, MOHAMMAD, & Pourheidar, Elham. (2022). The Association between the Level of Glycosylated Hemoglobin and the Immunogenicity of the Rubella Vaccination. NOVELTY IN BIOMEDICINE, 10(1), 9-11. SID. https://sid.ir/paper/1020696/en

Vancouver: Copy

HAGHIGHI MEHRDAD, GOUDARZI MEHDI, SISTANIZAD MOHAMMAD, Pourheidar Elham. The Association between the Level of Glycosylated Hemoglobin and the Immunogenicity of the Rubella Vaccination. NOVELTY IN BIOMEDICINE[Internet]. 2022;10(1):9-11. Available from: https://sid.ir/paper/1020696/en

IEEE: Copy

MEHRDAD HAGHIGHI, MEHDI GOUDARZI, MOHAMMAD SISTANIZAD, and Elham Pourheidar, “The Association between the Level of Glycosylated Hemoglobin and the Immunogenicity of the Rubella Vaccination,” NOVELTY IN BIOMEDICINE, vol. 10, no. 1, pp. 9–11, 2022, [Online]. Available: https://sid.ir/paper/1020696/en

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