@THE EFFECT OF AEROBIC TRAINING ON CARDIAC EXPRESSION OF MIR-126 IN DIABETIC AND HEALTHY RATS

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HADI HAMDOLLAH; GAEINI ABBASALI; MOTAMEDI PEJHMAN; RAJABI HAMID

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:148 Page(s): 44-55

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Title

@THE EFFECT OF AEROBIC TRAINING ON CARDIAC EXPRESSION OF MIR-126 IN DIABETIC AND HEALTHY RATS

Author(s)

HADI HAMDOLLAH | GAEINI ABBASALI | MOTAMEDI PEJHMAN | RAJABI HAMID | Issue Writer Certificate

Keywords

AEROBIC TRAININGQ1

ANGIOGENESISQ2

MIR126Q1

DIABETESQ2

Abstract

Background: AEROBIC TRAINING is well supported as a useful component of an exercise. One of the most common adaptations that occur in this type of training is creating new vessels and increased ANGIOGENESIS factors. AEROBIC TRAINING can be effective on ANGIOGENESIS. The aim of this study was to investigate the effect of AEROBIC TRAINING on cardiac expression of mir-126 in normal and diabetic rats.Methods: 35 Rats divided to two categories, diabetic and non-diabetics rats. Then each category of diabetic and non diabetic animals divided to two groups: under training and non-training. Cardiac muscle was removed and immediately placed into liquid nitrogen. Cardiac expression of mir-126 investigated in rat cardiac muscle using Real-time PCR. For data analysis, One-way ANOVA and post-hoc Tukey’s test were used.Results: The study results showed DIABETES significantly decreases cardiac expression of MIR126 and 8 weeks of AEROBIC TRAINING significantly increases cardiac expression of MIR126 in healthy and diabetic rats.Conclusion: It seems AEROBIC TRAINING can prevent negative effects of DIABETES via angiogenic path. Thus, kindle regulatory processes by MIR126 that via AEROBIC TRAINING are impressed, could be worthy strategy on development of new theraphy methods in DIABETES treatment.

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