Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model

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Nikoozadeh A.R.; POUZESH JADIDI R.; Nourazar M.R.; Asgharpour Arshad M.; BASHIRI J.

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Journal: Feyz Medical Sciences Journal Year:2022 | Volume:26 | Issue:4 Page(s): 398-406

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Title

Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model

Author(s)

Keywords

Aerobic exercise

Curcumin

Myocardial infarction

Peroxisome proliferator activated receptor alpha

PGC1-α

Citrate synthase

Abstract

Background: Mitochondrial dysfunction is one of the possible mechanisms for the progression of heart disease. This study aimed to effect of eight weeks of aerobic training and Curcumin supplementation on PGC1-α,gene expression and cardiomyocyte mitochondrial Citrate synthase in Cardiomyocytes of male rats with Myocardial infarction model. Materials and Methods: 40 male rats were randomly divided into 5 groups: healthy control, heart Myocardial infarction control, Aerobic exercise, supplement and exercise + supplement. The training and training+supplement groups were influenced by training on the intelligent electronic animal treadmill for 8 weeks, 5 days a week. At this time, the Myocardial infarction control and supplement groups had no exercise program. First, healthy controls were killed. Expression of PGC1-α,gene and mitochondrial Citrate synthase using real-time PCR method, the obtained data were analyzed using Shapiro-Wilk test, two-way and one-way analysis of variance and Tukey's post hoc test. Result: Results showed that the expression of PGC1-α,and Citrate synthase of cardiomyocytes in the groups trained with and without Curcumin consumption is significantly higher than the supplemented and Myocardial infarction control groups (P=0. 001). No significant difference was observed between the two groups of exercise and exercise + supplement. The expression of both genes in the Myocardial infarction control group was lower than that of healthy controls (P≤, 0. 05). Conclusion: Eight weeks of Aerobic exercise alone and in combination with Curcumin increased the expression of PGC1-α,gene and Citrate synthase. The combined effect of exercise and Curcumin were nonsignificantly greater.

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APA: Copy

Nikoozadeh, A.R., POUZESH JADIDI, R., Nourazar, M.R., Asgharpour Arshad, M., & BASHIRI, J.. (2022). Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model. FEYZ, 26(4 ), 398-406. SID. https://sid.ir/paper/1022817/en

Vancouver: Copy

Nikoozadeh A.R., POUZESH JADIDI R., Nourazar M.R., Asgharpour Arshad M., BASHIRI J.. Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model. FEYZ[Internet]. 2022;26(4 ):398-406. Available from: https://sid.ir/paper/1022817/en

IEEE: Copy

A.R. Nikoozadeh, R. POUZESH JADIDI, M.R. Nourazar, M. Asgharpour Arshad, and J. BASHIRI, “Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model,” FEYZ, vol. 26, no. 4 , pp. 398–406, 2022, [Online]. Available: https://sid.ir/paper/1022817/en

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