Genes Predisposing to Monogenic, Polygenic, and Syndromic Obesity: A Review of Current Trends and Prospects for Standard Obesity Genetic Testing

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Yahaya Tajudeen; Oladele Esther; Shemishere Ufuoma; Liman Umar Usman; Gomo Clement Boniface; Abubakar Aminu L.; Marafa Balkisu Muhammad

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Obesity Year:2022 | Volume:14 | Issue:4 Page(s): 248-264

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Information Journal Paper

Title

Genes Predisposing to Monogenic, Polygenic, and Syndromic Obesity: A Review of Current Trends and Prospects for Standard Obesity Genetic Testing

Author(s)

Keywords

Adiposity

Body weight

Hyperphagia

Leptin

Obesity

Abstract

Objective: The burden of Obesity is currently enormous, necessitating a novel strategy to complement the existing ones. Accordingly, genetic predisposition is suspected in many cases of the disease, which can potentially be used as therapeutic targets. However, there are differing viewpoints on the suspect genes, prompting the current review to articulate the genes and their mechanisms. Eight (16%) of the genes singularly predispose humans to Obesity (called monogenic Obesity), 22 (43%) interact with other genes and the environment to predispose humans to Obesity (called polygenic Obesity), and 21 (41%) cause syndromic Obesity. Monogenic Obesity is often caused by three genes [the Leptin (LEP), the Leptin receptor (LEPR), and the melanocortin 4 receptor (MC4R) genes], polygenic Obesity [fat mass and Obesity-associated (FTO) gene], and syndromic Obesity (Prader-Willi Syndrome). These genes control food intake and energy expenditure, and so mutations in them cause overeating, Adiposity, and Hyperphagia. Based on these findings, two geneticallybased drugs, named recombinant human Leptin and setmelanotide, have been formulated and shown to significantly reduce food intake, Body weight, and fat mass. This suggests that when the genetic etiology of Obesity is fully understood, the disease’, s treatment and prevention will improve. Healthcare providers are urged to develop genetically-based personalized treatments for obese patients.

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APA: Copy

Yahaya, Tajudeen, Oladele, Esther, Shemishere, Ufuoma, Abubakar, Aminu L., Marafa, Balkisu Muhammad, Liman, Umar Usman, & Gomo, Clement Boniface. (2022). Genes Predisposing to Monogenic, Polygenic, and Syndromic Obesity: A Review of Current Trends and Prospects for Standard Obesity Genetic Testing. IRANIAN JOURNAL OF DIABETES AND OBESITY, 14(4), 248-264. SID. https://sid.ir/paper/1023563/en

Vancouver: Copy

Yahaya Tajudeen, Oladele Esther, Shemishere Ufuoma, Abubakar Aminu L., Marafa Balkisu Muhammad, Liman Umar Usman, Gomo Clement Boniface. Genes Predisposing to Monogenic, Polygenic, and Syndromic Obesity: A Review of Current Trends and Prospects for Standard Obesity Genetic Testing. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2022;14(4):248-264. Available from: https://sid.ir/paper/1023563/en

IEEE: Copy

Tajudeen Yahaya, Esther Oladele, Ufuoma Shemishere, Aminu L. Abubakar, Balkisu Muhammad Marafa, Umar Usman Liman, and Clement Boniface Gomo, “Genes Predisposing to Monogenic, Polygenic, and Syndromic Obesity: A Review of Current Trends and Prospects for Standard Obesity Genetic Testing,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 14, no. 4, pp. 248–264, 2022, [Online]. Available: https://sid.ir/paper/1023563/en

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