IN VITRO INHIBITORY EFFECT OF RECOMBINANT HUMAN CALPROTECTIN ON K562 CELL LINE

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TAHERI ZAHRA; TUKMECHI AMIR; NOJAVAN MAJID; IMANI MEHDI

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Journal: Razi Journal of Medical Sciences Year:2015 | Volume:22 | Issue:134 Page(s): 91-100

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Title

IN VITRO INHIBITORY EFFECT OF RECOMBINANT HUMAN CALPROTECTIN ON K562 CELL LINE

Author(s)

TAHERI ZAHRA | TUKMECHI AMIR | NOJAVAN MAJID | IMANI MEHDI | Issue Writer Certificate

Keywords

K562Q2

RECOMBINANT HUMAN CALPROTECTINQ2

ANTICANCER PROPERTIESQ2

Abstract

Background: RECOMBINANT HUMAN CALPROTECTIN is a protein that has inhibitory effect on the growth of cancer. This substance could use as a marker or therapeutic agents for cancer. The goal of this study was to evaluate the anti-tumor property of RECOMBINANT HUMAN CALPROTECTIN on K562 cell line.Methods: RECOMBINANT HUMAN CALPROTECTIN was cloned and purified in E. coli. Then, different concentrations (1, 5, 10, 20, 40, 80 and 100 mg/ml) were prepared in Roswell Park Memorial Institute (RPMI) and its antitumor property against K562 was assayed by MTT method at the presence of Doxorubicin as positive standard.Results: Results showed RECOMBINANT HUMAN CALPROTECTIN has antitumor property against K562 cell line in a concentration and time dependent manner. Statistical analysis revealed RECOMBINANT HUMAN CALPROTECTIN significantly (P= 0.0231) has inhibitory effect on the growth on K562.Conclusion: Based on this finding we conclude that RECOMBINANT HUMAN CALPROTECTIN has anti-cancer properties, but its application needs further studies.

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APA: Copy

TAHERI, ZAHRA, TUKMECHI, AMIR, NOJAVAN, MAJID, & IMANI, MEHDI. (2015). IN VITRO INHIBITORY EFFECT OF RECOMBINANT HUMAN CALPROTECTIN ON K562 CELL LINE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 22(134), 91-100. SID. https://sid.ir/paper/10280/en

Vancouver: Copy

TAHERI ZAHRA, TUKMECHI AMIR, NOJAVAN MAJID, IMANI MEHDI. IN VITRO INHIBITORY EFFECT OF RECOMBINANT HUMAN CALPROTECTIN ON K562 CELL LINE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2015;22(134):91-100. Available from: https://sid.ir/paper/10280/en

IEEE: Copy

ZAHRA TAHERI, AMIR TUKMECHI, MAJID NOJAVAN, and MEHDI IMANI, “IN VITRO INHIBITORY EFFECT OF RECOMBINANT HUMAN CALPROTECTIN ON K562 CELL LINE,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 22, no. 134, pp. 91–100, 2015, [Online]. Available: https://sid.ir/paper/10280/en

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