Association of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with varicose veins in Mazandaran population

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Fallahpour Masomeh; Abdullahpour Rohullah; NEMATI FARKHONDEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:172 Page(s): 18-26

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

759

Download:

Cites:

Information Journal Paper

Title

Association of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with varicose veins in Mazandaran population

Author(s)

Fallahpour Masomeh | Abdullahpour Rohullah | NEMATI FARKHONDEH | Issue Writer Certificate

Keywords

Varicose veinsQ1

Methylenetetrahydrofolate reductase (MTHFR)Q2

C677T polymorphismQ1

Abstract

Background: Methylenetetrahydrofolate reductase (MTHFR) is one of the key enzymes in the metabolism of folate, and the mutation of C677T leads to reduction of MTHFR enzyme activity and increases the risk of cardiovascular diseases. The aim of this study was to investigate the association between C677T polymorphism in MTHFR gene and some non-genetic factors and Varicose veins. Methods: In this case-control study, 80 patients with Varicose veins and 150 healthy subjects were studied. After extraction of DNA from peripheral blood, genotyping was performed by PCR-RFLP. Demographic data such as family history, sex, age, weight, work duration, defecation status, exercise, blood pressure, cigarette smoking were also recorded. Logistic regression method was used to investigate the association between Varicose veins disease and C677T genotypes and other recorded variables. Results: Genotype frequencies of C677T in MTHFR gene in patients and control groups was not significantly different (p>0. 05). The frequency of mutant allele in two groups was equal to 19%. The association between C577T genotype and Varicose veins was not significant (p>0. 05), however family history, weight, work duration and constipation was related to Varicose veins (p<0. 05). There was no association between Varicose veins and exercise, age, blood pressure, sex and cigarette smoking (p>0. 05). Conclusion: The polymorphism of C677T in MTHFR gene was not a determinant factor of the Varicose veins disease in Mazandaran population.

Cites

No record.

References

No record.

Cite

APA: Copy

Fallahpour, Masomeh, Abdullahpour, Rohullah, & NEMATI, FARKHONDEH. (2018). Association of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with varicose veins in Mazandaran population. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(172 ), 18-26. SID. https://sid.ir/paper/10301/en

Vancouver: Copy

Fallahpour Masomeh, Abdullahpour Rohullah, NEMATI FARKHONDEH. Association of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with varicose veins in Mazandaran population. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(172 ):18-26. Available from: https://sid.ir/paper/10301/en

IEEE: Copy

Masomeh Fallahpour, Rohullah Abdullahpour, and FARKHONDEH NEMATI, “Association of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with varicose veins in Mazandaran population,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 172 , pp. 18–26, 2018, [Online]. Available: https://sid.ir/paper/10301/en

Related Journal Papers