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Information Journal Paper

Title

COMPARISON OF CARDIOVASCULAR EFFECTS OF RIBES KHORASSANICUM FRACTIONS WITH ITS TOTAL EXTRACT IN NORMOTENSIVE RATS

Pages

  9-15

Abstract

 BACKGROUND AND OBJECTIVE Ribes khorassanicum has beneficial cardiovascular effects in normotensive and hypertensive animals. For further investigation, the effect of three fractions of aqueous (polar), ethyl acetate (polar and non-polar) and n-hexane (non-polar) of the plant s hydroalcoholic extract on cardiovascular parameters in normotensive rats was compared with its total extract. METHODS In this experimental study, 42 rats were divided into 7 groups (6 in each group): control, three doses of total extract 4, 12 and 24 mg/kg and three fractions of aqueous, ethyl acetate and n-hexane (20 mg/kg). Femoral artery cannulation and heart rate (HR), mean arterial pressure (MAP) and systolic blood pressure (SBP) were recorded throughout the experiment and then the changes (Δ, : difference before and after injection) were calculated and statistically analyzed. FINDINGS 24 mg/kg of the extract significantly increased Δ, HR (117. 5±, 11. 6 beats per minute) compared to control (5. 3±, 2. 7, p<0. 001) and 12 mg/kg of the extract significantly decreased Δ, MAP (-15. 1±, 2. 8 mm Hg) and Δ, SBP (-18. 4±, 3 mm Hg) compared to the control (p<0. 05). The fractions increased Δ, HR, which was not significant but was significant compared to 24 mg/kg of the extract (p<0. 05). Furthermore, the increase of Δ, MAP and Δ, SBP in n-hexane fraction (19. 45±, 3. 1 mm Hg and 34. 6±, 11. 5 mm Hg, respectively) was significant compared to the control and 12 mg/kg of the extract (p<0. 01 to p<0. 05). CONCLUSION The active ingredients in the cardiovascular effects of Ribes khorassanicum extract are spread in all fractions and the total extract has a better effect than each of the fractions alone due to its various non-polar and polar compounds as well as the synergistic effect.

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    APA: Copy

    MOHEBBATI, R., Kamkar Del, Yasamin, Hamounpeyma, I., ALIKHANI, V., DARROUDI, H., & SHAFEI, M.N.. (2021). COMPARISON OF CARDIOVASCULAR EFFECTS OF RIBES KHORASSANICUM FRACTIONS WITH ITS TOTAL EXTRACT IN NORMOTENSIVE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 23(1 ), 9-15. SID. https://sid.ir/paper/1030683/en

    Vancouver: Copy

    MOHEBBATI R., Kamkar Del Yasamin, Hamounpeyma I., ALIKHANI V., DARROUDI H., SHAFEI M.N.. COMPARISON OF CARDIOVASCULAR EFFECTS OF RIBES KHORASSANICUM FRACTIONS WITH ITS TOTAL EXTRACT IN NORMOTENSIVE RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2021;23(1 ):9-15. Available from: https://sid.ir/paper/1030683/en

    IEEE: Copy

    R. MOHEBBATI, Yasamin Kamkar Del, I. Hamounpeyma, V. ALIKHANI, H. DARROUDI, and M.N. SHAFEI, “COMPARISON OF CARDIOVASCULAR EFFECTS OF RIBES KHORASSANICUM FRACTIONS WITH ITS TOTAL EXTRACT IN NORMOTENSIVE RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 23, no. 1 , pp. 9–15, 2021, [Online]. Available: https://sid.ir/paper/1030683/en

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