Neutrophil-to-Lymphocyte Ratio Cut-Off Point for COVID-19 Mortality: A Retrospective Study

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Kheyri Zahedin; Metanat Sepehr; HOSAMIRUDSARI HADISEH; AKBARPOUR SAMANEH; Shojaei Maryam; Faraji Neda; MANSOURI FARIBA; TAGHIZADEH FATEMEH; AHMADIAN FATEMEH

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Journal: ACTA MEDICA IRANICA Year:2022 | Volume:60 | Issue:1 Page(s): 32-39

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Title

Neutrophil-to-Lymphocyte Ratio Cut-Off Point for COVID-19 Mortality: A Retrospective Study

Author(s)

Keywords

Blood cell count

Neutrophil-to-lymphocyte ratio

Coronavirus disease 2019 (COVID-19)

Mortality

Intensive care units

Abstract

Several months have passed since the onset of the COVID-19 pandemic. Multiple characteristics have been proposed as prognostic factors so far. This study aims to provide evidence on the association of neutrophil-to-lymphocyte ratio (NLR) at the hospitalization time and three desired outcomes (mortality, prolonged hospitalization, and intensive care unit [ICU] admission). We designed a single-centre retrospective observational study in Baharloo Hospital (Tehran, Iran) from 20 February to 19 April 2020. Patients with confirmed COVID-19 diagnosis via rt-PCR or chest CT imaging were included. Demographic and clinical data were obtained. The sample was divided into three groups, using tertile boundaries of initial NLR. The differences in mortality, comorbidities, hospitalization duration, drug administration, and ICU admission between these three groups were investigated. The identified confounding factors were adjusted to calculate the odds ratio of death, ICU admission, and prolonged hospitalization. Nine hundred sixty-three patients were included. In total, 151 and 212 participants experienced mortality and ICU admission, respectively. In multivariate logistic regression models, the adjusted odds ratio for mortality event in the second and third tertile of initial NLR after full adjustment were 1. 89 (95% CI: 1. 07-3. 32) and 2. 57 (95% CI: 1. 48-4. 43) and for ICU admission were 1. 85 (95% CI: 1. 14-3. 01) and 2. 88 (95% CI: 1. 79-4. 61), respectively. The optimal cut-off value of the initial NLR for predicting mortality was 4. 27. Initial NLR can predict mortality and ICU admission in COVID-19 patients. Further investigations for curating the calculated cut-off can propose initial NLR as an indicator of poor prognosis for COVID-19 patients.

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APA: Copy

Kheyri, Zahedin, Metanat, Sepehr, HOSAMIRUDSARI, HADISEH, AKBARPOUR, SAMANEH, Shojaei, Maryam, Faraji, Neda, MANSOURI, FARIBA, TAGHIZADEH, FATEMEH, & AHMADIAN, FATEMEH. (2022). Neutrophil-to-Lymphocyte Ratio Cut-Off Point for COVID-19 Mortality: A Retrospective Study. ACTA MEDICA IRANICA, 60(1), 32-39. SID. https://sid.ir/paper/1040629/en

Vancouver: Copy

Kheyri Zahedin, Metanat Sepehr, HOSAMIRUDSARI HADISEH, AKBARPOUR SAMANEH, Shojaei Maryam, Faraji Neda, MANSOURI FARIBA, TAGHIZADEH FATEMEH, AHMADIAN FATEMEH. Neutrophil-to-Lymphocyte Ratio Cut-Off Point for COVID-19 Mortality: A Retrospective Study. ACTA MEDICA IRANICA[Internet]. 2022;60(1):32-39. Available from: https://sid.ir/paper/1040629/en

IEEE: Copy

Zahedin Kheyri, Sepehr Metanat, HADISEH HOSAMIRUDSARI, SAMANEH AKBARPOUR, Maryam Shojaei, Neda Faraji, FARIBA MANSOURI, FATEMEH TAGHIZADEH, and FATEMEH AHMADIAN, “Neutrophil-to-Lymphocyte Ratio Cut-Off Point for COVID-19 Mortality: A Retrospective Study,” ACTA MEDICA IRANICA, vol. 60, no. 1, pp. 32–39, 2022, [Online]. Available: https://sid.ir/paper/1040629/en

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