Immune Checkpoint Inhibitors Induced Hepatotoxicity,Gastroenterologists' Perspectives

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Farshidpour Maham; Hutson William

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Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2022 | Volume:14 | Issue:2 Page(s): 244-253

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Information Journal Paper

Title

Immune Checkpoint Inhibitors Induced Hepatotoxicity,Gastroenterologists' Perspectives

Author(s)

Farshidpour Maham | Hutson William | Issue Writer Certificate

Keywords

Liver injury

Checkpoint inhibitors

Immune-related adverse events

Abstract

BACKGROUND: Immune Checkpoint inhibitors (ICIs) have promising clinical activity and are essential medications for patients with several malignancies. However, by deranging the immune system, these novel agents could lead to Immune-related adverse events (IRAEs). Hepatotoxicity with Checkpoint inhibitors usually results in acute hepatitis or drug-induced Liver injury. METHODS: This review article discusses the recent clinical evidence available regarding checkpoint inhibitor-induced hepatitis and reviews an approach to their diagnosis and management. RESULTS: The rate of Liver injury with ICIs varies between different Checkpoint inhibitors. It has been reported that the incidence of various grades of autoimmune hepatotoxicity with CTLA-4 inhibitors is between 3%-9%. The clinical characteristics of ICIs-induced hepatotoxicity are quite heterogeneous but they are usually in line with an autoimmune induced Liver injury. Management of severe ICIs-related hepatitis should consist of termination of the ICI and treatment with corticosteroids. CONCLUSION: ICIs have improved patients’,outcomes with different forms of malignancy,however, ICIs-related liver damage is a clinically significant entity in these patients. All patients should be monitored carefully for IRAEs while undergoing treatment with ICIs.

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APA: Copy

Farshidpour, Maham, & Hutson, William. (2022). Immune Checkpoint Inhibitors Induced Hepatotoxicity,Gastroenterologists' Perspectives. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 14(2), 244-253. SID. https://sid.ir/paper/1045677/en

Vancouver: Copy

Farshidpour Maham, Hutson William. Immune Checkpoint Inhibitors Induced Hepatotoxicity,Gastroenterologists' Perspectives. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2022;14(2):244-253. Available from: https://sid.ir/paper/1045677/en

IEEE: Copy

Maham Farshidpour, and William Hutson, “Immune Checkpoint Inhibitors Induced Hepatotoxicity,Gastroenterologists' Perspectives,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 14, no. 2, pp. 244–253, 2022, [Online]. Available: https://sid.ir/paper/1045677/en

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