Development of a new quantification method using partial volume effect correction for individual energy peaks in 111 Inpentetreotide SPECT/CT

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YAMASHITA KOSUKE; Miyaji Noriaki; Motegi Kazuki; TERAUCHI TAKASHI; ITO SHIGEKI

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Journal: Asia Oceania Journal of Nuclear Medicine & Biology Year:2022 | Volume:10 | Issue:2 Page(s): 126-137

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Title

Development of a new quantification method using partial volume effect correction for individual energy peaks in 111 Inpentetreotide SPECT/CT

Author(s)

Keywords

Single Photon Emission

Computed Tomography (SPECT)

111In-pentetreotide

Somatostatin receptor

scintigraphy (SRS)

Indium Uptake Index (IUI)

Partial Volume Effect (PVE)

Abstract

Objective(s): Somatostatin receptor scintigraphy (SRS) using 111 In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in 111 In-pentetreotide single-photon emission computed tomography (SPECT). Methods: Phantom experiments were performed to construct a new quantitative method. In the phantom experiments, a NEMA IEC body phantom was used. Acquisition was performed using two energy peaks (171 keV and 245 keV) on the SPECT/CT system. The volume of interest was set at each hot sphere and lung insert in the SPECT images of each energy peak, and the recovery coefficient (RC) was calculated to understand the PVE. A new quantitative index, the indium uptake index (IUI), was calculated using the RC to correct the PVE. The quantitative accuracy of the IUI in the hot sphere was confirmed. Case studies were performed to clarify the quantitative accuracy. In a case study, the relationship between the IUI and the Krenning score, which is used as a visual assessment, was evaluated for each lesion. Results: The obtained RCs showed that the energy peak at 171 keV was faster in recovering the effect of PVE than that at 245 keV. The IUI in the 17-mm-diameter hot sphere was overestimated by 4. 8% and 8. 3% at 171 keV and 245 keV, respectively, compared to the actual IUIs. The relationship between IUI and Krenning score was rs=0. 773 (p<0. 005) at sum, rs=0. 739 (p<0. 005) at 171 keV, and rs=0. 773 (p<0. 005) at 245 keV. Conclusion: We have developed a new quantification method for 111 In-pentetreotide SPECT/CT using RC-based PVE correction for an individual energy peak of 171 keV. The quantitative accuracy of this method was high even for accumulations of less than 20 mm, and it showed a good relationship with the Krenning score,therefore, the clinical usefulness of IUI was demonstrated.

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APA: Copy

YAMASHITA, KOSUKE, Miyaji, Noriaki, Motegi, Kazuki, TERAUCHI, TAKASHI, & ITO, SHIGEKI. (2022). Development of a new quantification method using partial volume effect correction for individual energy peaks in 111 Inpentetreotide SPECT/CT. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 10(2), 126-137. SID. https://sid.ir/paper/1045763/en

Vancouver: Copy

YAMASHITA KOSUKE, Miyaji Noriaki, Motegi Kazuki, TERAUCHI TAKASHI, ITO SHIGEKI. Development of a new quantification method using partial volume effect correction for individual energy peaks in 111 Inpentetreotide SPECT/CT. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2022;10(2):126-137. Available from: https://sid.ir/paper/1045763/en

IEEE: Copy

KOSUKE YAMASHITA, Noriaki Miyaji, Kazuki Motegi, TAKASHI TERAUCHI, and SHIGEKI ITO, “Development of a new quantification method using partial volume effect correction for individual energy peaks in 111 Inpentetreotide SPECT/CT,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 10, no. 2, pp. 126–137, 2022, [Online]. Available: https://sid.ir/paper/1045763/en

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