Miswak sticks? extract anti-inflammatory properties in carrageenan test

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HEMATI KARIM; Mehrzadi Saeed; BAKHTIARIAN AZAM; MOTEVALIAN MANIJEH; NIKOUEI VIDA; Foroohandeh Mehrdad; Karimi Mohammad Yahya; NIKOUEI vahid

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:25 | Issue:10 Page(s): 38-45

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Title

Miswak sticks? extract anti-inflammatory properties in carrageenan test

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Keywords

Salvadora persica L.Q3

Anti-inflammatory EffectQ2

CarrageenanQ2

RatsQ2

Abstract

Background: Miswak is the product of Salvadora persica L. that has antibacterial, antifungal, antiplasmudium, anticonvulsant, and gastroprotective properties. In this study, the Anti-inflammatory Effect of aqueous extract of miswak sticks (Salvadora persica L. ) was investigated in Carrageenan-induced rat paw edema. Methods: Adult male Rats were divided into five groups, receiving normal saline, indomethacin (5 mg/kg), extract of Salvadora persica L. (50, 75, and 100 mg/kg), intraperitoneally. Then, Carrageenan was injected into plantar surface of paw, and edema was measured using a micrometer in different times. Results: Salvadora persica L. extract at dose of 50 mg/kg reduced inflammation at 4 and 5 hours after Carrageenan injection (p<0. 05). Doses of 75 mg/kg (p<0. 01) and 100 mg/kg (p<0. 001) of this extract exerted Anti-inflammatory Effects at 4, 5, and 6 hours after Carrageenan injection. Indomethacin also decreased edema, significantly compared to saline-injected group (p<0. 0001). Conclusion: Our data revealed that Salvadora persica L. extract possesses anti-inflammatory properties. However, further experiments on the possible use of this plant in inflammatory disorders are required.

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APA: Copy

HEMATI, KARIM, Mehrzadi, Saeed, BAKHTIARIAN, AZAM, MOTEVALIAN, MANIJEH, NIKOUEI, VIDA, Foroohandeh, Mehrdad, Karimi, Mohammad Yahya, & NIKOUEI, vahid. (2019). Miswak sticks? extract anti-inflammatory properties in carrageenan test. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(10 ), 38-45. SID. https://sid.ir/paper/10484/en

Vancouver: Copy

HEMATI KARIM, Mehrzadi Saeed, BAKHTIARIAN AZAM, MOTEVALIAN MANIJEH, NIKOUEI VIDA, Foroohandeh Mehrdad, Karimi Mohammad Yahya, NIKOUEI vahid. Miswak sticks? extract anti-inflammatory properties in carrageenan test. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;25(10 ):38-45. Available from: https://sid.ir/paper/10484/en

IEEE: Copy

KARIM HEMATI, Saeed Mehrzadi, AZAM BAKHTIARIAN, MANIJEH MOTEVALIAN, VIDA NIKOUEI, Mehrdad Foroohandeh, Mohammad Yahya Karimi, and vahid NIKOUEI, “Miswak sticks? extract anti-inflammatory properties in carrageenan test,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 10 , pp. 38–45, 2019, [Online]. Available: https://sid.ir/paper/10484/en

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