EFFECT OF WHITE MULBERRY LEAVES HYDRO-ALCOHOLIC EXTRACT ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT'S HIND PAW

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ARZI A.; REZAEI MOHSEN; AGHEL N.; NOURI MOMBEYNI S.

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Journal: Jundishapur Scientific Medical Journal Year:2009 | Volume:8 | Issue:2 (61) Page(s): 149-156

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Information Journal Paper

Title

EFFECT OF WHITE MULBERRY LEAVES HYDRO-ALCOHOLIC EXTRACT ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT'S HIND PAW

Author(s)

ARZI A. | REZAEI MOHSEN | AGHEL N. | NOURI MOMBEYNI S. | Issue Writer Certificate

Keywords

WHITE MULBERRYQ3

INFLAMMATIONQ2

CARRAGEENANQ2

ASPIRINQ2

RATQ2

Abstract

Background and objective: Reviews of literature indicate that hydro- alcoholic extract of WHITE MULBERRY leaves, possesses anti-inflammatory effects such as inhibition of nitric oxide, PGE2 and cytokines, which urged us to examine the anti-inflammatory effect of this leaves hydro-alholic extract on CARRAGEENAN- induced paw edema in RAT.Materials and Methods: Hydroalcoholic extract of WHITE MULBERRY (Morus alba) leaves was prepared by ethanol (70% V/V) and soxhlet's method. The RATs grouped as: Intraperitoneal (ip) extract receiving (200, 400, 600 mg/kg), positive control (aspirin 300 mg/kg) and group that received saline. Thirty minutes following the ip injection of materials, CARRAGEENAN (1% W/V) was injected into the RAT's hind paw and the changes in RAT's paw edema was assessed by plethysmometer for five hours at intervals of one hour.Results: Compared with ASPIRIN, 200 and 400 mg/kg doses of extract had lower effect on reduction of RAT's paw edema (P<0.001). However, there was no significant difference between the group that received 600 mg/kg extract and ASPIRIN group.Conclusion: Hydro-alcoholic extract of Morus alba leaves at 600 mg/kg dose similar to ASPIRIN (300 mg/kg), significantly reduced the paw edema of RATs and showed effective anti-inflammatory activity.

Cites

ABORTIFICIENT EFFECT OF MULBERRY WHITE ROOT IN MICE

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APA: Copy

ARZI, A., REZAEI, MOHSEN, AGHEL, N., & NOURI MOMBEYNI, S.. (2009). EFFECT OF WHITE MULBERRY LEAVES HYDRO-ALCOHOLIC EXTRACT ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT'S HIND PAW. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 8(2 (61)), 149-156. SID. https://sid.ir/paper/12923/en

Vancouver: Copy

ARZI A., REZAEI MOHSEN, AGHEL N., NOURI MOMBEYNI S.. EFFECT OF WHITE MULBERRY LEAVES HYDRO-ALCOHOLIC EXTRACT ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT'S HIND PAW. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2009;8(2 (61)):149-156. Available from: https://sid.ir/paper/12923/en

IEEE: Copy

A. ARZI, MOHSEN REZAEI, N. AGHEL, and S. NOURI MOMBEYNI, “EFFECT OF WHITE MULBERRY LEAVES HYDRO-ALCOHOLIC EXTRACT ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RAT'S HIND PAW,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 8, no. 2 (61), pp. 149–156, 2009, [Online]. Available: https://sid.ir/paper/12923/en

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