THE INHIBITORY EFFECT OF CAPTOPRIL ON PARAQUAT TOXICITY IN MITOCHONDRIA ISOLATED FROM THE RAT LIVER

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MOHAMMADI BARDBORI A.; GHAZI KHANSARI M.

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Journal: Journal of Kerman University of Medical Sciences Year:2006 | Volume:13 | Issue:3 Page(s): 132-140

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Title

THE INHIBITORY EFFECT OF CAPTOPRIL ON PARAQUAT TOXICITY IN MITOCHONDRIA ISOLATED FROM THE RAT LIVER

Author(s)

MOHAMMADI BARDBORI A. | GHAZI KHANSARI M. | Issue Writer Certificate

Keywords

PARAQUATQ2

RAT LIVER MITOCHONDRIAQ3

CAPTOPRILQ3

OXIDATIVE STRESSQ2

Abstract

Background: The aim of the present study was to show the capability of CAPTOPRIL as a thiol ACEi (angiotensin converting enzyme inhibitor), in suppressing mitochondrial toxicity due to PARAQUAT. Method: In this study, rats liver mitochondria were isolated with buffer using refrigerated centrifuge. In order to obtain the minimum toxic dose of PARAQUAT and the effective dose of CAPTOPRIL, different concentrations of PARAQUAT (1 to 100mM) and CAPTOPRIL (0.08 to 1mM) were investigated by determining LC50, viability indices, lipid peroxidation, mitochondrial swelling, catalase activity, GSH and GSSG. Results: Simultaneous treatment of mitochondria with CAPTOPRIL (0.08 mM) and PARAQUAT (5 mM) significantly ameliorate the mitochondrial toxicity of PARAQUAT (5 mM) alone. Our results show that CAPTOPRIL is a effective antioxidant. The antioxidative action of CAPTOPRIL appears to be attributable to the sulphahydryl group (SH) in the compound. This effect may be due to CAPTOPRIL abilities to scavenge reactive oxygen species. Conclusion: Our results indicate that CAPTOPRIL can ameliorate OXIDATIVE STRESS induced by PARAQUAT and therefore, can be used for the prevention and treatment of diseases caused by environmental toxins.

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APA: Copy

MOHAMMADI BARDBORI, A., & GHAZI KHANSARI, M.. (2006). THE INHIBITORY EFFECT OF CAPTOPRIL ON PARAQUAT TOXICITY IN MITOCHONDRIA ISOLATED FROM THE RAT LIVER. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 13(3), 132-140. SID. https://sid.ir/paper/105/en

Vancouver: Copy

MOHAMMADI BARDBORI A., GHAZI KHANSARI M.. THE INHIBITORY EFFECT OF CAPTOPRIL ON PARAQUAT TOXICITY IN MITOCHONDRIA ISOLATED FROM THE RAT LIVER. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;13(3):132-140. Available from: https://sid.ir/paper/105/en

IEEE: Copy

A. MOHAMMADI BARDBORI, and M. GHAZI KHANSARI, “THE INHIBITORY EFFECT OF CAPTOPRIL ON PARAQUAT TOXICITY IN MITOCHONDRIA ISOLATED FROM THE RAT LIVER,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 3, pp. 132–140, 2006, [Online]. Available: https://sid.ir/paper/105/en

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