EXPRESSION OF BRCA1 PROTEIN IN INVASIVE AND IN SITU CARCINOMAS AND ITS RELATION WITH MARKER OF BREAST CANCER STEM CELLS (CD44) AND PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARIMI KIVI A.; MADJD Z.; HASHEMI F.; MOLANAE S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2010 | Volume:17 | Issue:80-81 Page(s): 16-24

Download Full-Text

Persian Verion

View:

1,311

Download:

Cites:

Information Journal Paper

Title

EXPRESSION OF BRCA1 PROTEIN IN INVASIVE AND IN SITU CARCINOMAS AND ITS RELATION WITH MARKER OF BREAST CANCER STEM CELLS (CD44) AND PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS

Author(s)

KARIMI KIVI A. | MADJD Z. | HASHEMI F. | MOLANAE S. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

CANCER STEM CELLQ2

PROGNOSTIC FACTORSQ3

CD44Q2

BRCA1Q3

Abstract

Introduction: BREAST CANCER is the most common cancer and the second cause of cancer death among women. Despite recent developments in therapeutic tools about 25% of all the involved cases die annually. The clinical, molecular, and pathologic features of BREAST CANCER in BRCA1 mutation carriers suggest that BRCA1 may function as a stem-cell regulator. The purpose of the current study was to investigate the correlation between BRCA1 protein expression and clinicopathological characteristics, and putative CANCER STEM CELL marker (CD44) in breast carcinomas.Methods: In this experimental study, immunohistochemistry was performed on 156 primary operable breast tumors employing a monoclonal anti-BRCA1 primary antibody. The relation between BRCA1 expression and variations such as age and pathologic features andCD44 was studied by Chi square test. SPSS V.16 was also used for data analysis.Results: Altered BRCA1 expression was significantly associated with high grade and poor prognosis breast tumors (p=0.006). Mutated BRCA1 was also more often seen in early onset BREAST CANCER patients (£ 40 years) rather than patients over age of 40 (p=0.04). There was also a significant correlation between the BRCA1 andCD44 expression (p=0.02).Conclusion: Our results indicated that mutated BRCA1 expression is a marker of tumor aggressiveness, and its expression related to BREAST CANCER stem markerCD44 in primary breast tumors. These finding support the idea that loss of BRCA1 expression may result in an accumulation of genetically unstable breast stem cells, providing targets for further carcinogenic events.

Cites

No record.

References

No record.

Cite

APA: Copy

KARIMI KIVI, A., MADJD, Z., HASHEMI, F., & MOLANAE, S.. (2010). EXPRESSION OF BRCA1 PROTEIN IN INVASIVE AND IN SITU CARCINOMAS AND ITS RELATION WITH MARKER OF BREAST CANCER STEM CELLS (CD44) AND PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 17(80-81), 16-24. SID. https://sid.ir/paper/10536/en

Vancouver: Copy

KARIMI KIVI A., MADJD Z., HASHEMI F., MOLANAE S.. EXPRESSION OF BRCA1 PROTEIN IN INVASIVE AND IN SITU CARCINOMAS AND ITS RELATION WITH MARKER OF BREAST CANCER STEM CELLS (CD44) AND PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2010;17(80-81):16-24. Available from: https://sid.ir/paper/10536/en

IEEE: Copy

A. KARIMI KIVI, Z. MADJD, F. HASHEMI, and S. MOLANAE, “EXPRESSION OF BRCA1 PROTEIN IN INVASIVE AND IN SITU CARCINOMAS AND ITS RELATION WITH MARKER OF BREAST CANCER STEM CELLS (CD44) AND PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 80-81, pp. 16–24, 2010, [Online]. Available: https://sid.ir/paper/10536/en

Related Journal Papers