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Information Journal Paper

Title

A STUDY ON BLASTOCYST IMPLANTATION AND RELATED HISTOLOGICAL CHANGES OF THE ENDOMETRIUM IN MICE

Pages

  10-17

Abstract

 Background: BLASTOCYST formation and IMPLANTATION in the uterus is a complicated aspect of embryology. Any abnormal IMPLANTATION in this critical stage may lead to pregnancy failure. There are still some ambiguities regarding the IMPLANTATION process. The aim of this study was to investigate BLASTOCYST development along with changes in the ENDOMETRIUM. Materials and Methods: One hundred and fifty outbred mice were kept under standard conditions with an appropriate light cycle (12 hours dark, 12 hours light). Then, every two female mice were placed in a cage with one male mouse overnight. Observation of the vaginal plug was considered as the first day of pregnancy. The mice were then killed from the fourth to seventh day of pregnancy at three different hours (8,12 and 18) by cervical dislocation. The uterus was then dissected, and tissue processing was done. The blocks containing specimens were cut serially and stained by hematoxilyn-eosin. The specimens were later studied under the light microscope and photomicrographs were prepared. Results: Results showed that BLASTOCYST attachment took place at the antimesometrial zone. The endometrial changes also occurred at the primary decidual zone and then extended toward other zones. The endometrial changes observed included edema, leukocyte infiltration and decidua-trophoblast adhesion. Conclusion: Considering the fact that access to human specimens is not easy, most of the studies carried out so far have focused on mice, and although this study has also been conducted on an animal model, the results may be generalized to humans as well.

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    APA: Copy

    BAHMANPOUR, S.. (2003). A STUDY ON BLASTOCYST IMPLANTATION AND RELATED HISTOLOGICAL CHANGES OF THE ENDOMETRIUM IN MICE. JOURNAL OF MEDICAL RESEARCH (JMR), 1(3), 10-17. SID. https://sid.ir/paper/105818/en

    Vancouver: Copy

    BAHMANPOUR S.. A STUDY ON BLASTOCYST IMPLANTATION AND RELATED HISTOLOGICAL CHANGES OF THE ENDOMETRIUM IN MICE. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2003;1(3):10-17. Available from: https://sid.ir/paper/105818/en

    IEEE: Copy

    S. BAHMANPOUR, “A STUDY ON BLASTOCYST IMPLANTATION AND RELATED HISTOLOGICAL CHANGES OF THE ENDOMETRIUM IN MICE,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 1, no. 3, pp. 10–17, 2003, [Online]. Available: https://sid.ir/paper/105818/en

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