THE EFFECT OF HIGH DOSE PROGESTERONE ON SKIN ALLOGRAFT SURVIVAL FROM NEWBORN TO MOTHER IN RATS

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ZARIFKAR A.A.; AI J.; DEHGHANI S.; HOSSEINI F.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2002 | Volume:1 | Issue:1 Page(s): 1-8

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Title

THE EFFECT OF HIGH DOSE PROGESTERONE ON SKIN ALLOGRAFT SURVIVAL FROM NEWBORN TO MOTHER IN RATS

Author(s)

ZARIFKAR A.A. | AI J. | DEHGHANI S. | HOSSEINI F. | Issue Writer Certificate

Keywords

PROGESTERONEQ3

SKIN GRAFTQ3

ALLOGRAFTQ4

SURVIVAL TIME CORRESPONDENCEQ4

Abstract

Background: Previous studies have shown that PROGESTERONE can alter the immune response and a high level of this hormone in pregnancy has a substantial role in blastocyst implantation and fetus survival. Since a fetus can be regarded as an ALLOGRAFT for the mother, it seems that high levels of PROGESTERONE may have the same effect on other types of grafts. In the present study, the effect of high dose PROGESTERONE administration on skin ALLOGRAFT survival was investigated in rats. Materials and Methods: Sixty-one female rats and their newborns were divided into four groups. Three groups of mother rats received medroxy PROGESTERONE acetate (6.5, 16.5, 25 mg/kg, I.M.) in a single dose. In the control group (n=14), mother rats received the same volume of vehicle. After five days, a full thickness SKIN GRAFT was obtained from the back (interscapular region) of the The dressing at the grafted sites were changed every day and observed for any rejection signs including graft infiltration, scar formation and graft loss. Biopsies from SKIN GRAFTs were prepared for histopathological studies. Results: Graft survival time of the groups that received PROGESTERONE in high doses were significantly more than Conclusion: High dose PROGESTERONE administration can have an ameliorative effect on skin ALLOGRAFTs and can prolong survival time.

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APA: Copy

ZARIFKAR, A.A., AI, J., DEHGHANI, S., & HOSSEINI, F.. (2002). THE EFFECT OF HIGH DOSE PROGESTERONE ON SKIN ALLOGRAFT SURVIVAL FROM NEWBORN TO MOTHER IN RATS. JOURNAL OF MEDICAL RESEARCH (JMR), 1(1), 1-8. SID. https://sid.ir/paper/105859/en

Vancouver: Copy

ZARIFKAR A.A., AI J., DEHGHANI S., HOSSEINI F.. THE EFFECT OF HIGH DOSE PROGESTERONE ON SKIN ALLOGRAFT SURVIVAL FROM NEWBORN TO MOTHER IN RATS. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2002;1(1):1-8. Available from: https://sid.ir/paper/105859/en

IEEE: Copy

A.A. ZARIFKAR, J. AI, S. DEHGHANI, and F. HOSSEINI, “THE EFFECT OF HIGH DOSE PROGESTERONE ON SKIN ALLOGRAFT SURVIVAL FROM NEWBORN TO MOTHER IN RATS,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 1, no. 1, pp. 1–8, 2002, [Online]. Available: https://sid.ir/paper/105859/en

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