LONG-TERM FOLLOW-UP OF PATIENTS WITH HAIRY CELL LEUKEMIA AFTER TREATMENT WITH 2-CHLORODEOXY ADENOSINE

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RAMZI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2002 | Volume:1 | Issue:1 Page(s): 20-26

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Title

LONG-TERM FOLLOW-UP OF PATIENTS WITH HAIRY CELL LEUKEMIA AFTER TREATMENT WITH 2-CHLORODEOXY ADENOSINE

Author(s)

RAMZI M. | Issue Writer Certificate

Keywords

HAIRY CELL LEUKEMIAQ4

2-CHLORODEOXY ADENOSINEQ4

CHEMOTHERAPYQ3

SECONDARY MALIGNANCYQ3

Abstract

Background: HAIRY CELL LEUKEMIA (HCL) is a chronic B cell disorder that follows an indolent but progressive course. The ability of the new purine analogue deoxyadenosine to induce long-term complete remission in patients with HAIRY CELL LEUKEMIA has revolutionized the treatment of this disease. In this clinical trial, we report the long term outcome of patients with HCL treated with this drug in Shiraz. Materials and Methods: From October 1993 to April 2002, 58 patients with symptomatic classic HAIRY CELL LEUKEMIA were treated with 2-CHLORODEOXY ADENOSINE (2-CdA) with a dose of 0.1 mg/kg of body weight per day by a continuous intravenous infusion for 7 days.Results: Fifty patients (86.2%) achieved an initial complete remission and 7 (12.0%) showed a partial response. The patients were followed up for a mean duration of 63 months. Five patients (10%) relapsed after a mean of 43 months, all of whom received a second course of 2-CdA. Four of the patients (80%) achieved a second complete response and one (20%) had a partial response. No case of SECONDARY MALIGNANCY was observed after treatment with 2-CdA over a mean follow-up period of 63 months. Conclusion: A single course of 2-CdA induced a long-term remission in the vast majority of patients with HCL. Relapse rate for complete responders was low. Patients who relapsed were successfully retreated with a second course of this drug. It can be concluded that 2-CdA has high efficacy with a low rate of acute and long-term toxicity with no increased risk of development of a SECONDARY MALIGNANCY.

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APA: Copy

RAMZI, M.. (2002). LONG-TERM FOLLOW-UP OF PATIENTS WITH HAIRY CELL LEUKEMIA AFTER TREATMENT WITH 2-CHLORODEOXY ADENOSINE. JOURNAL OF MEDICAL RESEARCH (JMR), 1(1), 20-26. SID. https://sid.ir/paper/105863/en

Vancouver: Copy

RAMZI M.. LONG-TERM FOLLOW-UP OF PATIENTS WITH HAIRY CELL LEUKEMIA AFTER TREATMENT WITH 2-CHLORODEOXY ADENOSINE. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2002;1(1):20-26. Available from: https://sid.ir/paper/105863/en

IEEE: Copy

M. RAMZI, “LONG-TERM FOLLOW-UP OF PATIENTS WITH HAIRY CELL LEUKEMIA AFTER TREATMENT WITH 2-CHLORODEOXY ADENOSINE,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 1, no. 1, pp. 20–26, 2002, [Online]. Available: https://sid.ir/paper/105863/en

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