Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats

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JAFARI ADELEH; ROSTAMPOUR MOHAMMAD; Ataei Azam; KHAKPOUR TALEGHANI BEHROOZ

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Journal Paper

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Journal: KOOMESH Year:2022 | Volume:24 | Issue:4 (90) Page(s): 531-537

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Title

Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats

Author(s)

JAFARI ADELEH | ROSTAMPOUR MOHAMMAD | Ataei Azam | KHAKPOUR TALEGHANI BEHROOZ

Keywords

Open Field Test

Grooming

Dizocilpine Maleate

Exercise

Abstract

Introduction: Exploratory behaviors in rodents are an indicator of anxiety behaviors. In the present study, the combined effect of aerobic exercise with different intensities and inhibition of the glutamate system on exploratory behavior in rats was investigated. Materials and Methods: In this experimental study, 80 male Wistar rats were randomly divided into 10 groups including control, diazepam (0. 6 mg/kg), two doses of MK-801 (0. 1 and 0. 05 mg/kg), two groups of acute aerobic exercise (low and moderate intensity), two acute aerobic exercise groups (low and moderate intensity) + dose 0. 1 MK801, the two groups performing acute aerobic exercise (low and moderate intensity) + dose 0. 05 MK-801. On the test day, immediately after exerciseو drugs were injected, and 30 minutes later, exploratory behaviors were assessed by an open field. Results: Low and moderate-intensity exercise with MK-801 at a dose of 0. 05 mg/kg significantly increased the frequency of rearing and decreased the number of grooming, and frequency of defecation compared to control and MK-801 groups (P<0. 01, P<0. 01 and P<0. 05, respectively). In addition, performing low and medium intensity exercise with MK-801 at a dose of 0. 1 mg/kg significantly increased the number of rearing and decreased the number of grooming, and frequency of defecation compared to control and MK-801 groups (P<0. 001, P<0. 001 and P<0. 05, respectively). Conclusion: The results of the present study suggest that the use of exercise in combination with NMDA inhibition can be effective on anxiety-induced exploratory behaviors in animals.

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Effect of treadmill exercise on glutamate transporter proteins and acetylcholinesterase activity in the prefrontal cortex of diabetic rats

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APA: Copy

JAFARI, ADELEH, ROSTAMPOUR, MOHAMMAD, Ataei, Azam, & KHAKPOUR TALEGHANI, BEHROOZ. (2022). Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats. KOOMESH, 24(4 (90) ), 531-537. SID. https://sid.ir/paper/1059327/en

Vancouver: Copy

JAFARI ADELEH, ROSTAMPOUR MOHAMMAD, Ataei Azam, KHAKPOUR TALEGHANI BEHROOZ. Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats. KOOMESH[Internet]. 2022;24(4 (90) ):531-537. Available from: https://sid.ir/paper/1059327/en

IEEE: Copy

ADELEH JAFARI, MOHAMMAD ROSTAMPOUR, Azam Ataei, and BEHROOZ KHAKPOUR TALEGHANI, “Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats,” KOOMESH, vol. 24, no. 4 (90) , pp. 531–537, 2022, [Online]. Available: https://sid.ir/paper/1059327/en

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