Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model

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Shafie Anahid; Kianian Farzaneh; ASHABI GHORBANGOL; KADKHODAEE MEHRI; RANJBARAN MINA; Hajiaqaei Mahdi; Lorian Keivan; Abdi Arash; SEIFI BEHJAT

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Journal: INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE Year:2022 | Volume:20 | Issue:11 Page(s): 941-954

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Title

Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model

Author(s)

Keywords

Apoptosis genes

Hydrogen sulfide

Oxidative stress

Sperm count

Testosterone

Varicocele

Abstract

Background: Despite the effectiveness of testosterone therapy in conditions associated with testosterone deficiency, including varicocele, several dose-dependent side effects limit the clinical use of testosterone therapy. Hydrogen sulfide, a toxic gas in high concentrations but a beneficial molecule in low concentrations, acts as both a major effector and an important inducer of testosterone. Objective: This study investigated whether a subeffective dose of testosterone combined with a subeffective dose of hydrogen sulfide donor sodium hydrosulfide (NaHS) can be effective in an experimental varicocele model through a possible additive effect. Materials and Methods: Thirty Wistar rats weighing 200-250 gr were divided into 5 groups as (n = 6/each): sham, varicocele, testosterone (200 μ, g/kg, 5 times per wk for 4 consecutive weeks), NaHS (15 μ, mol/L, daily for 4 consecutive wk) and testosterone + NaHS (200 μ, g/kg, 5 times per wk + 15 μ, mol/L, daily, both for 4 consecutive wk). All animals, except in the sham group, underwent varicocele induction. Results: The coadministration of testosterone and NaHS significantly increased serum testosterone (10. 23 ±,0. 95, p = 0. 01), testicular H2S levels (608. 94 ±,21. 09, p < 0. 001), and testicular superoxide dismutase activity (66. 14 ±,1. 56, p < 0. 001), decreased malondialdehyde levels (0. 77 ±,0. 52, p < 0. 001), and B-cell lymphoma 2-associated X protein to B-cell lymphoma 2 (0. 16 ±,0. 01, p < 0. 001) protein expression ratio in the testicular tissues and improved sperm parameters and testicular histopathology compared to the varicocele group. Conclusion: The combination therapy of subeffective doses of testosterone and NaHS can attenuate the varicocele-induced damages by reducing testicular oxidative stress and apoptosis and thus can be considered an effective approach with fewer side effects.

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APA: Copy

Shafie, Anahid, Kianian, Farzaneh, ASHABI, GHORBANGOL, KADKHODAEE, MEHRI, RANJBARAN, MINA, Hajiaqaei, Mahdi, Lorian, Keivan, Abdi, Arash, & SEIFI, BEHJAT. (2022). Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 20(11), 941-954. SID. https://sid.ir/paper/1067163/en

Vancouver: Copy

Shafie Anahid, Kianian Farzaneh, ASHABI GHORBANGOL, KADKHODAEE MEHRI, RANJBARAN MINA, Hajiaqaei Mahdi, Lorian Keivan, Abdi Arash, SEIFI BEHJAT. Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2022;20(11):941-954. Available from: https://sid.ir/paper/1067163/en

IEEE: Copy

Anahid Shafie, Farzaneh Kianian, GHORBANGOL ASHABI, MEHRI KADKHODAEE, MINA RANJBARAN, Mahdi Hajiaqaei, Keivan Lorian, Arash Abdi, and BEHJAT SEIFI, “Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 20, no. 11, pp. 941–954, 2022, [Online]. Available: https://sid.ir/paper/1067163/en

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