The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L. ) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines

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Motafeghi Farzaneh; HABIBI EMRAN; Firozjaei Maryam; EGHBALI MOHAMMAD; Mortazavi Parham; Salmanmahiny Amirhossein; SHOKRZADEH MOHAMMAD

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Journal: Pharmaceutical and Biomedical Research Year:2023 | Volume:9 | Issue:1 Page(s): 27-36

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Title

The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L. ) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines

Author(s)

Keywords

Cytotoxicity

Cancer

Tarragon

Artemisia dracunculus L

Cell line

Abstract

Background: : Cancer is one of the problems facing societies today and despite new advances in chemotherapy and Cancer treatment, there are still many Cancers that do not respond to today’, s treatments. Tarragon with the scientific name of Artemisia dracunculus L. has various flavonoid and polyphenolic compounds and many therapeutic effects. Objectives: This study aimed to investigate the Cytotoxicity of this plant on different categories of Cancer cels. Methodes: After collecting the shoots of Tarragon and extracting them by the maceration method, the weight of the extract with a yield of 22. 25% was 12. 9 g. After examining the presence of flavonoids and total phenol, the extract’, s antioxidant activity was examined using DPPH and FRAP methods. Finally, MTT tests on three Cancer Cell lines, MCF-7, HT-29, and MKN45, were done using different concentrations of Tarragon extract (100, 200, 500, and 1000 μ, g/mL). Results: Total flavonoids were detected at 24±, 1. 18 mg of quercetin per gram of extract, and total phenols were detected at 59±, 2. 21 mg of gallic acid per gram of extract. Examining the inhibitory effect of DPPH compared to vitamin C, it was found that the hydroalcoholic extract of Tarragon has a 50% inhibitory effect. According to the standard curve, the amount of iron reduced by Tarragon hydroalcoholic extract is equal to 405±, 0. 11 μ, g/ml. The cytotoxic effect of Tarragon hydroalcoholic extract on MCF7, MKN45, and HT-29 Cell lines was investigated, and their IC50 values were 1065. 669, 881. 19, and 743. 870 μ, g/mL, respectively. The A. dracunculus L extract inhibits the growth of Cancer cells in various Cell lines. Conclusion: According to antioxidant tests, it can be said that the anti-Cancer effects of Tarragon are based on its antioxidant power and phenolic and flavonoid compounds.

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APA: Copy

Motafeghi, Farzaneh, HABIBI, EMRAN, Firozjaei, Maryam, EGHBALI, MOHAMMAD, Mortazavi, Parham, Salmanmahiny, Amirhossein, & SHOKRZADEH, MOHAMMAD. (2023). The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L. ) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 9(1), 27-36. SID. https://sid.ir/paper/1068637/en

Vancouver: Copy

Motafeghi Farzaneh, HABIBI EMRAN, Firozjaei Maryam, EGHBALI MOHAMMAD, Mortazavi Parham, Salmanmahiny Amirhossein, SHOKRZADEH MOHAMMAD. The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L. ) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2023;9(1):27-36. Available from: https://sid.ir/paper/1068637/en

IEEE: Copy

Farzaneh Motafeghi, EMRAN HABIBI, Maryam Firozjaei, MOHAMMAD EGHBALI, Parham Mortazavi, Amirhossein Salmanmahiny, and MOHAMMAD SHOKRZADEH, “The Cytotoxic Effect of the Tarragon (Artemisia dracunculus L. ) Hydroalcoholic Extract on the HT-29, MKN45, and MCF-7 Cell Lines,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 9, no. 1, pp. 27–36, 2023, [Online]. Available: https://sid.ir/paper/1068637/en

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