The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel

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Salmanvandi Mohsen; Haramshahi Seyed Mohammad Amin; Mansouri Elahe; ALIZADEH AKRAM

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Journal: BASIC AND CLINICAL NEUROSCIENCE Year:2023 | Volume:14 | Issue:1 Page(s): 117-128

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Title

The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel

Author(s)

Salmanvandi Mohsen | Haramshahi Seyed Mohammad Amin | Mansouri Elahe | ALIZADEH AKRAM | Issue Writer Certificate

Keywords

Rosmarinic acid

Neural differentiation

Hydrogel

Chitosan (CH)

Wharton’

s jelly-derived mesenchymal stem cells (WJMSCs)

Abstract

Introduction: Numerous studies have shown the positive effects of rosmarinic acid on the nervous system. Rosmarinic acid as a herbal compound with anti-inflammatory effects can prevent thedestructive effect of inflammation on the nervous system. Furthermore, various studies haveemphasized the advantages of three-dimensional (3D) culture over the twodimensional (2D) culture of cells. Methods: In this study, thermosensitive chitosan (CH)-based hydrogel as a 3D scaffoldwith the combination of chitosan, beta-glycerol phosphate and hydroxyl ethyl cellulose (CH-GP-HEC) loaded with rosmarinic acid was used to induce neuronal differentiation in humanWharton jelly stem cells. Also, cells were divided into eight groups to evaluate the effect of 3Dcell culture and to compare gene expression in different induction conditions. Results: The results ofgene expression analysis showed the highest expression of neuronal markers in Whartons jelly derived mesenchymal stem cells (WJMSCs) cultured in chitosan, beta-glycerol phosphate and hydroxyl ethyl cellulose (ch-gp-hec) loaded with differentiation medium androsmarinic acid. According to the results of gene expression, rosmarinic acid alone has a positiveeffect on the induction of expression of neural markers. This positive effect is enhanced by cellculture in 3D conditions. Conclusion: This study shows that rosmarinic acid can be considered an inexpensiveand available compound for use in neural tissue engineering. The results of this study indicatethat rosmarinic acid can be considered a cheap and available compound for use in neural tissueengineering.

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APA: Copy

Salmanvandi, Mohsen, Haramshahi, Seyed Mohammad Amin, Mansouri, Elahe, & ALIZADEH, AKRAM. (2023). The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel. BASIC AND CLINICAL NEUROSCIENCE, 14(1), 117-128. SID. https://sid.ir/paper/1070589/en

Vancouver: Copy

Salmanvandi Mohsen, Haramshahi Seyed Mohammad Amin, Mansouri Elahe, ALIZADEH AKRAM. The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2023;14(1):117-128. Available from: https://sid.ir/paper/1070589/en

IEEE: Copy

Mohsen Salmanvandi, Seyed Mohammad Amin Haramshahi, Elahe Mansouri, and AKRAM ALIZADEH, “The Effect of Rosmarinic Acid on Neural Differentiation of Wartons Jelly-derived Mesenchymal Stem Cells in Two-dimensional and Three-dimensional Cultures using Chitosan-based Hydrogel,” BASIC AND CLINICAL NEUROSCIENCE, vol. 14, no. 1, pp. 117–128, 2023, [Online]. Available: https://sid.ir/paper/1070589/en

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