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Cites:

1

Information Journal Paper

Title

An overview of the anti-tumor effects of Silibinin

Pages

  116-129

Abstract

Silibinin is a major component of silymarin (Silybum marianum), which has traditionally been used to treat a wide range of liver diseases. Recently, Silibinin and its derivatives in both in vitro and in vivo models have shown a significant inhibitory effect in different types of Tumors including skin, breast, lung, colon, bladder, prostate, kidney and liver. The chemo-preventive potentials of this flavonoid are promoted by inducing Apoptosis, enhancing Tumor suppressor and cell cycle inhibitors, inhibiting growth factors, and attenuating proliferative mediators. In this paper, a summary of the important molecular mechanisms involved in Silibinin anti-cancer effects, animal studies and important clinical trials have been presented. The results of these studies will provide a more comprehensive perspective of Silibinin and help to optimize its effects in cancer chemotherapy.

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  • Cite

    APA: Copy

    Mashhadi Akbar Boojar, Mahdi, MASHHADI AKBAR BOOJAR, MASOUD, & Golmohammad, Sepide. (2019). An overview of the anti-tumor effects of Silibinin. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(12 ), 116-129. SID. https://sid.ir/paper/10752/en

    Vancouver: Copy

    Mashhadi Akbar Boojar Mahdi, MASHHADI AKBAR BOOJAR MASOUD, Golmohammad Sepide. An overview of the anti-tumor effects of Silibinin. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;25(12 ):116-129. Available from: https://sid.ir/paper/10752/en

    IEEE: Copy

    Mahdi Mashhadi Akbar Boojar, MASOUD MASHHADI AKBAR BOOJAR, and Sepide Golmohammad, “An overview of the anti-tumor effects of Silibinin,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 12 , pp. 116–129, 2019, [Online]. Available: https://sid.ir/paper/10752/en

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