AN OVERVIEW ON THE EFFECTS OF SILIBININ ON DIFFERENT MICRORNAS EXPRESSION IN CANCER

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AKBARI KORDKHEYLI VAHID; ZARPOU SETAREH; NABIPUR EHSAN; TAFAZOLI ALIREZA; BAGHERI ABOUZAR

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Journal: Journal of Mazandaran University of Medical Sciences Year:2018 | Volume:28 | Issue:165 Page(s): 213-229

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Title

AN OVERVIEW ON THE EFFECTS OF SILIBININ ON DIFFERENT MICRORNAS EXPRESSION IN CANCER

Author(s)

Keywords

SILIBININQ1

MIRNAQ1

CANCERQ2

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of about 60% of humangenomes. SILIBININ or mixture of silybin A and B is a flavonolignans that constitute 70-80% Silymarin whichis considered to be its main effective ingredient. SILIBININ revealed antioxidant and anti-inflammatory effectsby scavenging free radicals, improving antioxidant enzymatic activities, and suppressing NF-к β activation. One of the recent discoveries about the functions of SILIBININ, is its ability to change different MIRNAsexpression, especially in CANCER. For instance, SILIBININ decreases Bcl2 level by inhibiting miR-21 expressionin breast CANCER cells that leads to apoptosis. SILIBININ elevates miR-203 expression in lung CANCER cells thatcauses stimulation of E-cadherin. The component can differentiate mesenchymal phonotype to epithelial. Also, treatment of glioblastoma CANCER cells with SILIBININ diminishes anti-apoptosis factor XIAP byupregulation of miR-7 that causes prevention of autophagia in these cells. Therefore, SILIBININ could induceapoptosis and differentiation and inhibit proliferation in different CANCER cells via regulation of variousmiRNAs expression. In this review study we aimed to summarize the studies about the effects of SILIBININ ondifferent MIRNAs expression in various types of CANCER cells to distinguish the exact mechanism of SILIBININanti-cancer effects.

Cites

Effects of silibinin on hepatic warm ischemia-reperfusion injury in the rat model

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APA: Copy

AKBARI KORDKHEYLI, VAHID, ZARPOU, SETAREH, NABIPUR, EHSAN, TAFAZOLI, ALIREZA, & BAGHERI, ABOUZAR. (2018). AN OVERVIEW ON THE EFFECTS OF SILIBININ ON DIFFERENT MICRORNAS EXPRESSION IN CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 213-229. SID. https://sid.ir/paper/45361/en

Vancouver: Copy

AKBARI KORDKHEYLI VAHID, ZARPOU SETAREH, NABIPUR EHSAN, TAFAZOLI ALIREZA, BAGHERI ABOUZAR. AN OVERVIEW ON THE EFFECTS OF SILIBININ ON DIFFERENT MICRORNAS EXPRESSION IN CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):213-229. Available from: https://sid.ir/paper/45361/en

IEEE: Copy

VAHID AKBARI KORDKHEYLI, SETAREH ZARPOU, EHSAN NABIPUR, ALIREZA TAFAZOLI, and ABOUZAR BAGHERI, “AN OVERVIEW ON THE EFFECTS OF SILIBININ ON DIFFERENT MICRORNAS EXPRESSION IN CANCER,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 213–229, 2018, [Online]. Available: https://sid.ir/paper/45361/en

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