Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis

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KADEH HAMIDEH; Arbabi Kalati Fereshte; Ramezaninejad Mahdi

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Journal: Journal of Dentistry Year:2023 | Volume:24 | Issue:SUPPLEMENT (1) Page(s): 125-131

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Title

Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis

Author(s)

KADEH HAMIDEH | Arbabi Kalati Fereshte | Ramezaninejad Mahdi | Issue Writer Certificate

Keywords

E-cadherin

N-cadherin

Periodontitis

Etiology

Abstract

Statement of the Problem: E-cadherin and N-cadherin are two types of cell adhesion mole-cules that are involved in organ development, wound healing, and pathological conditions through the process of epithelial-mesenchymal transition (EMT). However, their role has not yet been fully elucidated in the pathogenesis of periodontal diseases. Purpose: To determine the expression level of proteins associated with the EMT process (E-cadherin and N-cadherin) in chronic Periodontitis. Materials and Method: In this cross-sectional study, 37 samples (19 cases with healthy gingival tissue and 18 cases with severe chronic Periodontitis) that referred to the Periodon-tology Department of Zahedan Dental School, Zahedan, Iran, in 2018 were included. The samples were immunohistochemically stained with E-cadherin and N-cadherin monoclonal antibodies. Afterward, the percentage of stained cells and the staining intensity of the cells were evaluated. Finally, the obtained data were analyzed using by IBM©,SPSS©,Statistics version 21 using Mann-Whitney statistical test. Results: In this study, 89. 5% of the healthy gingival tissue samples and 61. 1% of samples with chronic Periodontitis showed E-cadherin expression in more than 50% of cells. This difference between the two groups was not significant (p= 0. 13),however, the E-cadherin staining intensity of the healthy gingival tissue was strong while that of the samples with chronic Periodontitis was moderate (p= 0. 002). The N-cadherin expression was negative in 68. 4% of healthy gingival cases, while 50% of the cases with chronic Periodontitis showed a high expression of N-cadherin. This difference was statistically significant (p= 0. 04). More-over, the N-cadherin staining intensity also had a significant difference between the two groups (p= 0. 004). Conclusion: Based on the results of the present study, the increased expression of N-cadherin and reduction of staining intensity of E-cadherin was found in chronic Periodontitis compared to healthy gingival tissues. Therefore, EMT process may be involved in the path-ogenesis of severe chronic Periodontitis.

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APA: Copy

KADEH, HAMIDEH, Arbabi Kalati, Fereshte, & Ramezaninejad, Mahdi. (2023). Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 24(SUPPLEMENT (1)), 125-131. SID. https://sid.ir/paper/1075478/en

Vancouver: Copy

KADEH HAMIDEH, Arbabi Kalati Fereshte, Ramezaninejad Mahdi. Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2023;24(SUPPLEMENT (1)):125-131. Available from: https://sid.ir/paper/1075478/en

IEEE: Copy

HAMIDEH KADEH, Fereshte Arbabi Kalati, and Mahdi Ramezaninejad, “Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. SUPPLEMENT (1), pp. 125–131, 2023, [Online]. Available: https://sid.ir/paper/1075478/en

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