GENE THERAPY APPROACHES TO REGENERATING THE MUSCULOSKELETAL SYSTEM

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SEDAGHATI BITA; EVANS CHRISTOPHER H.; HUARD JOHNNY

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:145 Page(s): 62-78

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Information Journal Paper

Title

GENE THERAPY APPROACHES TO REGENERATING THE MUSCULOSKELETAL SYSTEM

Author(s)

SEDAGHATI BITA | EVANS CHRISTOPHER H. | HUARD JOHNNY | Issue Writer Certificate

Keywords

GENE THERAPYQ2

MUSCULOSKELETAL SYSTEMQ1

REGENERATINGQ1

Abstract

Background: Injuries to the MUSCULOSKELETAL SYSTEM are common, debilitating and expensive. In many cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve repair and regeneration at sites of injury by enabling the local, sustained and potentially regulated expression of therapeutic gene products; such products include morphogens, growth factors and anti-inflammatory agents. Proteins produced endogenously as a result of gene transfer are nascent molecules that have undergone post-translational modification. In addition, gene transfer offers particular advantages for the delivery of products with an intracellular site of action, such as transcription factors and noncoding RNAs, and proteins that need to be inserted into a cell compartment, such as a membrane. Transgenes can be delivered by viral or nonviral vectors via in vivo or ex vivo protocols using progenitor or differentiated cells. The first gene transfer clinical trials for osteoarthritis and cartilage repair have already been completed. Various bone-healing protocols are at an advanced stage of development, including studies with large animals that could lead to human trials. Other applications in the repair and regeneration of skeletal muscle, intervertebral disc, meniscus, ligament and tendon are in preclinical development. In addition to scientific, medical and safety considerations, clinical translation is constrained by social, financial and logistical issues.

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APA: Copy

SEDAGHATI, BITA, EVANS, CHRISTOPHER H., & HUARD, JOHNNY. (2016). GENE THERAPY APPROACHES TO REGENERATING THE MUSCULOSKELETAL SYSTEM. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(145), 62-78. SID. https://sid.ir/paper/10755/en

Vancouver: Copy

SEDAGHATI BITA, EVANS CHRISTOPHER H., HUARD JOHNNY. GENE THERAPY APPROACHES TO REGENERATING THE MUSCULOSKELETAL SYSTEM. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;23(145):62-78. Available from: https://sid.ir/paper/10755/en

IEEE: Copy

BITA SEDAGHATI, CHRISTOPHER H. EVANS, and JOHNNY HUARD, “GENE THERAPY APPROACHES TO REGENERATING THE MUSCULOSKELETAL SYSTEM,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 145, pp. 62–78, 2016, [Online]. Available: https://sid.ir/paper/10755/en

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