THE PROTECTIVE EFFECT OF AGMATINE AGAINST INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED MEMORY IMPAIRMENT IN MALE RATS

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FARBOOD YAGHOUB; ZARIFKAR AMIR HOSSEIN; DIANAT MAHIN; SARKAKI ALIREZA; MOUSAVI MARYAM

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Journal: KNOWLEDGE AND HEALTH Year:2014 | Volume:9 | Issue:3 Page(s): 70-76

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Title

THE PROTECTIVE EFFECT OF AGMATINE AGAINST INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED MEMORY IMPAIRMENT IN MALE RATS

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Keywords

STREPTOZOTOCINQ2

AGMATINEQ3

LEARNINGQ3

MEMORYQ3

MORRIS WATER MAZEQ3

RATQ3

Abstract

Introduction: Intracerebroventricular injection of STREPTOZOTOCIN leads to LEARNING and MEMORY impairment. Different mechanisms such as oxidative stress and insulin signaling disruption has been proposed for streptozocin induced LEARNING and MEMORY deterioration. As these changes occur in Alzheimer's disease, this model is widely used to assess Alzheimer's disease. AGMATINE is a polyamine derived from L-arginine decarboxylation. AGMATINE is shown to have various effects such as neuroprotective role. Therefore, the present study was aimed to assess the plausible protective effect of AGMATINE against streptozocin induced MEMORY impairment.Methods: Male sprague-dawely RATs weighing 200-250 g were used in this study. Within surgery the canules were implanted bilaterally into lateral ventricle. Streptozocin was injected on days 1 and 3 (3 mg/kg in divided doses). AGMATINE administration (40 and 80 mg/kg) was started from day 4 and continued in an alternate manner till day 14. The animal’s LEARNING and MEMORY capability was assessed on days 15-18 using MORRIS WATER MAZE. The animals were trained during 3 days, and on day 4, the probe test was done. In order to assess the effect of drugs on motivation and sensorimotor coordination, a visible platform test was performed after the probe trial.Results: While streptozocin injection led to LEARNING and MEMORY disability, AGMATINE treatment in dose 80 mg/kg but not 40 mg/kg restored this MEMORY impairment.Conclusion: It seems that AGMATINE might be beneficial for MEMORY impairment caused by Alzheimer’s disease.

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APA: Copy

FARBOOD, YAGHOUB, ZARIFKAR, AMIR HOSSEIN, DIANAT, MAHIN, SARKAKI, ALIREZA, & MOUSAVI, MARYAM. (2014). THE PROTECTIVE EFFECT OF AGMATINE AGAINST INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED MEMORY IMPAIRMENT IN MALE RATS. KNOWLEDGE AND HEALTH, 9(3), 70-76. SID. https://sid.ir/paper/107827/en

Vancouver: Copy

FARBOOD YAGHOUB, ZARIFKAR AMIR HOSSEIN, DIANAT MAHIN, SARKAKI ALIREZA, MOUSAVI MARYAM. THE PROTECTIVE EFFECT OF AGMATINE AGAINST INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED MEMORY IMPAIRMENT IN MALE RATS. KNOWLEDGE AND HEALTH[Internet]. 2014;9(3):70-76. Available from: https://sid.ir/paper/107827/en

IEEE: Copy

YAGHOUB FARBOOD, AMIR HOSSEIN ZARIFKAR, MAHIN DIANAT, ALIREZA SARKAKI, and MARYAM MOUSAVI, “THE PROTECTIVE EFFECT OF AGMATINE AGAINST INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED MEMORY IMPAIRMENT IN MALE RATS,” KNOWLEDGE AND HEALTH, vol. 9, no. 3, pp. 70–76, 2014, [Online]. Available: https://sid.ir/paper/107827/en

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