EFFECT OF ADENYLYL CYCLASE INHIBITOR (SQ-22536) INJECTION IN ROSTRAL VENTROMEDIAL MEDULLA ON FORMALIN INDUCED NOCICEPTIVE BEHAVIOR IN RATS

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GOUDARZVAND M.; AZHDARI HASAN; KHAKPAY R.

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Journal: KNOWLEDGE AND HEALTH Year:2010 | Volume:4 | Issue:4 Page(s): 11-16

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Title

EFFECT OF ADENYLYL CYCLASE INHIBITOR (SQ-22536) INJECTION IN ROSTRAL VENTROMEDIAL MEDULLA ON FORMALIN INDUCED NOCICEPTIVE BEHAVIOR IN RATS

Author(s)

GOUDARZVAND M. | AZHDARI HASAN | KHAKPAY R. | Issue Writer Certificate

Keywords

ADENYLYL CYCLASE INHIBITORQ4

SQ-22536Q4

FORMALIN TESTQ3

ROSTRAL VENTROMEDIAL MEDULLAQ4

RATSQ3

Abstract

Introduction: Activation of the cyclic adenosine monophosphate (cAMP) pathway produces mechanical hyperalgesia, sensitizes nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription. This study examined the role of the cAMP pathway in a model of chronic pain, by assessing associated behavioral changes after inhibition of Adenylyl syclase in ROSTRAL VENTROMEDIAL MEDULLA (RVM). Methods: In this study, thirty-six Sprague- Dawley RATS (weighing 250-300 g) were divided into six groups including control, vehicle, sham and SQ-22536 (50, 100 and 200 nmol) groups. Formalin was injected into the right paws of all groups. Results: Intra-RVM injection of SQ-22536 (100 nmol) decreased formalin induced nociceptive pain in the 5th, 10th, 15th, 25th, 35th, 50th and 55th minutes. Also, SQ-22536 (200 nmol) decreased formalin induced nociceptive pain in the 15th minute.Conclusion: Therefore, inhibition of the adenylyl cyclase inhibitoion in the ROSTRAL VENTROMEDIAL MEDULLA decreases formalin induced nociceptive behaviors in RATS.

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APA: Copy

GOUDARZVAND, M., AZHDARI, HASAN, & KHAKPAY, R.. (2010). EFFECT OF ADENYLYL CYCLASE INHIBITOR (SQ-22536) INJECTION IN ROSTRAL VENTROMEDIAL MEDULLA ON FORMALIN INDUCED NOCICEPTIVE BEHAVIOR IN RATS. KNOWLEDGE AND HEALTH, 4(4), 11-16. SID. https://sid.ir/paper/107988/en

Vancouver: Copy

GOUDARZVAND M., AZHDARI HASAN, KHAKPAY R.. EFFECT OF ADENYLYL CYCLASE INHIBITOR (SQ-22536) INJECTION IN ROSTRAL VENTROMEDIAL MEDULLA ON FORMALIN INDUCED NOCICEPTIVE BEHAVIOR IN RATS. KNOWLEDGE AND HEALTH[Internet]. 2010;4(4):11-16. Available from: https://sid.ir/paper/107988/en

IEEE: Copy

M. GOUDARZVAND, HASAN AZHDARI, and R. KHAKPAY, “EFFECT OF ADENYLYL CYCLASE INHIBITOR (SQ-22536) INJECTION IN ROSTRAL VENTROMEDIAL MEDULLA ON FORMALIN INDUCED NOCICEPTIVE BEHAVIOR IN RATS,” KNOWLEDGE AND HEALTH, vol. 4, no. 4, pp. 11–16, 2010, [Online]. Available: https://sid.ir/paper/107988/en

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