A mini-review in Thyroid Function Test: More Than Meets Our Eye (Mini Review)

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Goswami Soumik; Chattopadhyay Mounam

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Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biochemistry Year:2023 | Volume:11 | Issue:1 Page(s): 88-91

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Title

A mini-review in Thyroid Function Test: More Than Meets Our Eye (Mini Review)

Author(s)

Goswami Soumik | Chattopadhyay Mounam | Issue Writer Certificate

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Abstract

Thyroid function tests (TFTs) happen to be the most commonly performed tests in endocrinology, leaving aside plasma glucose. Apparently though, it seems quite easy to interpret, but there are subtle nuances to it. If the test results are not analyzed thoroughly through clinico-biochemical tests, there are high chances of erroneous diagnosis and treatment. Two-site immunometric assays which are also known popularly as “, sandwich”,assays are used generally to measure thyroid stimulating hormone (TSH). In this study, we used two sets of antibodies: one bound to a solid phase known as “, capture antibody”,and the other labeled as “, detection antibody”, . The analyte forms a complex with these two antibodies, and as a result, a signal is generated which helps us measure the concentration of the analyte, namely, TSH. Sometimes certain human anti-animal antibodies (HAAAs) could be present in the serum of the individual. It is more commonly seen among those who received some sort of immunological therapy at any point in their life. They can cause both positive and negative interferences depending on their reactivity. If the HAAA is reactive both to capturing and detecting antibodies but not to the analyte, it will form a complex binding to both and generate a false high signal as if the analyte is present in high concentration in the sample. On the other hand, if the HAAA is only reactive to capture antibody and prevents binding of the analyte to it and forms a complex, it will not form any complex and will generate a falsely low signal as if the analyte is present in low concentration in the sample. Generally, human anti-mouse antibodies are found to cause such interactions. To alleviate this problem, some commercial assay systems use panels of antigens or pre-immune sera from source animals to mop up the HAAAs, but in practice, these polyspecific antibodies are quite difficult to remove from the sample (1-3). . .

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APA: Copy

Goswami, Soumik, & Chattopadhyay, Mounam. (2023). A mini-review in Thyroid Function Test: More Than Meets Our Eye (Mini Review). AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 11(1), 88-91. SID. https://sid.ir/paper/1080073/en

Vancouver: Copy

Goswami Soumik, Chattopadhyay Mounam. A mini-review in Thyroid Function Test: More Than Meets Our Eye (Mini Review). AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2023;11(1):88-91. Available from: https://sid.ir/paper/1080073/en

IEEE: Copy

Soumik Goswami, and Mounam Chattopadhyay, “A mini-review in Thyroid Function Test: More Than Meets Our Eye (Mini Review),” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 11, no. 1, pp. 88–91, 2023, [Online]. Available: https://sid.ir/paper/1080073/en

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