A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION

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KHOSRAVI AHMAD; NOURIAN M.; KHOSRAVI BOROUJENI H.; KALALIAN MOGHADAM H.; EBRAHIMI HOSSEIN

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Journal: KNOWLEDGE AND HEALTH Year:2007 | Volume:2 | Issue:3 Page(s): 47-55

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Title

A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION

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Keywords

LOW DENSITY LIPOPROTEINQ4

TRIGLYCERIDEQ4

FRIEDEWALDQ4

MODIFIED FRIEDEWA-LDQ4

DE-LONG AND DIRECT MEASUREMENTQ4

Abstract

Introduction: Reduction of LOW DENSITY LIPOPROTEIN cholesterol (LDL-C) in persons with coronary heart disease (CHD) is targeted. First step in treatment of lowering the LDL-C level is lifestyle modification including diet, weight reduction and exercise. At second step, the lipid lowering drug should be added. Although direct measurement of LDL-C from serum is most accurate, but it is not cost-effective, so laboratories usually use the FRIEDEWALD equation that suffers from several limitations such as hypertriglyceridemia and variability of lipoprotein composition. The authors compared and determined the correlation of LDL-C from enzymatic measurement with LDL-C from calculating.Methods and Materials: A total of 475 fasting serum samples (199 males and 276 females with mean age of 56.3 years) with TG less than 400 mg/ dl in Imam Hossein hospital (Shahroud) were analyzed. According to serum TG levels, samples divided in four groups (<100, 100-199, 200-299, 300-400). Authors calculated the LDL-C and then compared with direct measurement. Data analyzed with SPSS and table curve packages.Results: The comparison between direct and calculated methods showed that: 1) Concordance with the difference of 0±20 mg/dl is low. 2) FRIEDEWALD showed more accuracy compared with other calculated methods (51.2% versus 38.7% and 42.7%). 3) with the raising of TG, the accuracy declines and the overestimation increases. Correlation coefficient was 0.66.Conclusion: An overestimation of approximately 0±20 mg/dl was found in over 50% of samples comparison with direct LDL-C. Therefore; direct measurement of LDL-C in patients with CHD is recommented.

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References

COMPARING RESULTS OF SERUM LEVEL LDL-CHOLESTROL BY ENZYMATIC AND CALCULATED METHODS IN LABAFINEJAD HOSPITAL IN 1383-1384

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APA: Copy

KHOSRAVI, AHMAD, NOURIAN, M., KHOSRAVI BOROUJENI, H., KALALIAN MOGHADAM, H., & EBRAHIMI, HOSSEIN. (2007). A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION. KNOWLEDGE AND HEALTH, 2(3), 47-55. SID. https://sid.ir/paper/108070/en

Vancouver: Copy

KHOSRAVI AHMAD, NOURIAN M., KHOSRAVI BOROUJENI H., KALALIAN MOGHADAM H., EBRAHIMI HOSSEIN. A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION. KNOWLEDGE AND HEALTH[Internet]. 2007;2(3):47-55. Available from: https://sid.ir/paper/108070/en

IEEE: Copy

AHMAD KHOSRAVI, M. NOURIAN, H. KHOSRAVI BOROUJENI, H. KALALIAN MOGHADAM, and HOSSEIN EBRAHIMI, “A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION,” KNOWLEDGE AND HEALTH, vol. 2, no. 3, pp. 47–55, 2007, [Online]. Available: https://sid.ir/paper/108070/en

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