THE IMMUNOHISTOCHEMICAL COMPARATIVE EVALUATION OF CK13 AND CK18 EXPRESSION IN ODONTOGENIC CYSTS AND AMELOBLASTOMA

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DEYHIMI P.; DANESH ARDAKANI M.

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Title

THE IMMUNOHISTOCHEMICAL COMPARATIVE EVALUATION OF CK13 AND CK18 EXPRESSION IN ODONTOGENIC CYSTS AND AMELOBLASTOMA

Author(s)

DEYHIMI P. | DANESH ARDAKANI M. | Issue Writer Certificate

Keywords

RADICULAR CYSTQ2

DENTIGROUS CYSTQ2

OKCQ2

AMELOBLASTOMAQ1

CYTOKERATIN13Q2

CYTOKERATIN18Q2

IMMUNOHISTOCHEMISTRYQ1

Abstract

Statement of Problems: Evaluating cytokeratin contents of odontogenic cysts and tumors can be one of the important aspects in comparative study of these lesions.Purpose: The aim of this study was to evaluate expression of CK13 and CK18 in odontogenic cysts and AMELOBLASTOMAs.Materials and Methods: In this study, RADICULAR CYSTs (20 cases), dentigerous cysts (20 cases), OKC (20 cases), unicystic AMELOBLASTOMA (20 cases) and solid AMELOBLASTOMA (20 cases) were evaluated. Then, 3-4 m msections were prepared and stained with immuhistochemical procedure (avidin- biotin method. The obtained data by microscopic consideration was analyzed with statistical tests such as: Chi-square, Mann-Whitney, Wilcoxon (p <0.05).Results: All of the odontogenic cysts and cystic parts of unicystic AMELOBLASTOMA expressed CK13 in the upper layers (middle and superficial) more than the deeper ones (basal and parabasal). In AMELOBLASTOMAs, CK13 expression in stellate reticulum and acanthomatose component was more than preameloblasts. Expression of CK18 in the upper layers (middle and superficial) was more than deeper layers (basal and parabasal) in radicular and dentigerous cysts. Results of immunoreactivity with CK18 in OKC were negative in 100% of cases. In addition, AMELOBLASTOMAs (unicystic and solid) did have not significant differences in expression of CK13 and CK18. Conclusion: CK13 did not show any differences between these lesions but significant difference in CK18 expression at all 4 layers of the epithelium in odontogenic cysts and AMELOBLASTOMAs may indicate the different nature of these lesions and probably confirms this suggestion that unicystic AMELOBLASTOMA is initiated as a neoplasm essentially, no from neoplastic change of an odontogenic cyst, in particular dentigerous cyst. The same CK13 and CK18 expression pattern in unicystic and solid AMELOBLASTOMAs reveals the same biomolecular nature despite different gross and clinical features.

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APA: Copy

DEYHIMI, P., & DANESH ARDAKANI, M.. (2009). THE IMMUNOHISTOCHEMICAL COMPARATIVE EVALUATION OF CK13 AND CK18 EXPRESSION IN ODONTOGENIC CYSTS AND AMELOBLASTOMA. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 10(2 (23)), 111-121. SID. https://sid.ir/paper/108413/en

Vancouver: Copy

DEYHIMI P., DANESH ARDAKANI M.. THE IMMUNOHISTOCHEMICAL COMPARATIVE EVALUATION OF CK13 AND CK18 EXPRESSION IN ODONTOGENIC CYSTS AND AMELOBLASTOMA. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;10(2 (23)):111-121. Available from: https://sid.ir/paper/108413/en

IEEE: Copy

P. DEYHIMI, and M. DANESH ARDAKANI, “THE IMMUNOHISTOCHEMICAL COMPARATIVE EVALUATION OF CK13 AND CK18 EXPRESSION IN ODONTOGENIC CYSTS AND AMELOBLASTOMA,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 10, no. 2 (23), pp. 111–121, 2009, [Online]. Available: https://sid.ir/paper/108413/en

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