Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies

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TAJANI AMINEH SADAT; Amiri Tehranizadeh Zeinab; Pourmohammad Arianoosh; Pourmohammad Armin; IRANSHAHY MILAD; Farhadi Faegheh; SOHEILI VAHID; FAZLY BAZZAZ BIBI SEDIGHEH

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Journal: Iranian Journal of Basic Medical Sciences Year:2023 | Volume:26 | Issue:4 Page(s): 445-452

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Title

Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies

Author(s)

Keywords

Biofilm

Coumarin

Microbial resistance

Pseudomonas aeruginosa

Quorum sensing

Abstract

Objective(s): Biofilm-associated infections are challenging to manage or treat since the Biofilm matrix is impenetrable to most antibiotics. Therefore, the best approach to deal with Biofilm infections is to interrupt the construction during the initial levels. Biofilm formation has been regulated through the Quorum sensing (QS) network, making it an attractive target for any antibacterial therapy. Materials and Methods: Here, some Coumarin members, including umbelliprenin, 4-farnesyloxyCoumarin, gummosin, samarcandin, farnesifrol A, B, C, and auraptan, have been assessed as QS inhibitors in silico and in vitro. Their potential inhibitory effects on Biofilm formation and virulence factor production of Pseudomonas aeruginosa PAO1 were evaluated. Results: First, the interaction of these compounds was investigated against one of the major transcriptional regulator proteins, PqsR, using molecular docking and structural analysis methodology. After that, in vitro evaluations indicated that 4-farnesyloxyCoumarin and farnesifrol B showed considerable reduction in Biofilm formation (62% and 56%, respectively), virulence factor production, and synergistic effects with tobramycin. Moreover, 4-farnesyloxyCoumarin significantly (99. 5%) reduced PqsR gene expression. Conclusion: The Biofilm formation test, virulence factors production assays, gene expression analysis, and molecular dynamic simulations data demonstrated that Coumarin derivatives are a potential anti-QS family through PqsR inhibition.

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APA: Copy

TAJANI, AMINEH SADAT, Amiri Tehranizadeh, Zeinab, Pourmohammad, Arianoosh, Pourmohammad, Armin, IRANSHAHY, MILAD, Farhadi, Faegheh, SOHEILI, VAHID, & FAZLY BAZZAZ, BIBI SEDIGHEH. (2023). Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(4), 445-452. SID. https://sid.ir/paper/1085303/en

Vancouver: Copy

TAJANI AMINEH SADAT, Amiri Tehranizadeh Zeinab, Pourmohammad Arianoosh, Pourmohammad Armin, IRANSHAHY MILAD, Farhadi Faegheh, SOHEILI VAHID, FAZLY BAZZAZ BIBI SEDIGHEH. Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(4):445-452. Available from: https://sid.ir/paper/1085303/en

IEEE: Copy

AMINEH SADAT TAJANI, Zeinab Amiri Tehranizadeh, Arianoosh Pourmohammad, Armin Pourmohammad, MILAD IRANSHAHY, Faegheh Farhadi, VAHID SOHEILI, and BIBI SEDIGHEH FAZLY BAZZAZ, “Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 4, pp. 445–452, 2023, [Online]. Available: https://sid.ir/paper/1085303/en

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