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Information Journal Paper

Title

Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice

Pages

  478-485

Abstract

 Objective(s): The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER)results in a state known as “, ER stress”, . It can affect the fate of proteins and play a crucial role in the pathogenesis of several diseases. In this study, we investigated the protective effect of Chlorogenic acid (CA) on the Inflammation and Apoptosis of tunicamycin-induced ER stress in mice. Materials and Methods: We categorized mice into six groups: Saline, Vehicle, CA, TM, CA 20-TM, and CA 50-TM. The mice received CA (20 or 50 mg/kg) before intraperitoneal tunicamycin injection. After 72 hr of treatment, serum biochemical analysis, histopathological alterations, protein and/or mRNA levels of Steatosis, and inflammatory and apoptotic markers were investigated by ELISA and/or RT-PCR. Results: We found that 20 mg/kg CA decreased mRNA levels of Grp78, Ire-1, and Perk. Moreover, CA supplementation prevented TM-induced liver injury through changes in lipid accumulation and lipogenesis markers of Steatosis (Srebp-1c, Ppar-α, , and Fas), and exerted an inhibitory effect on inflammatory (NF-κ, B, Tnf-α, , and Il-6) and apoptotic markers (caspase 3, p53, Bax, and Bcl2), of liver tissue in ER stress mice. Conclusion: These data suggest that CA ameliorates hepatic Apoptosis and Inflammation by reducing NF-κ, B and Caspase 3 as related key factors between Inflammation and Apoptosis.

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    APA: Copy

    MOSLEHI, AZAM, KOMEILI MOVAHHED, TAHEREH, Ahmadian, Mostafa, GHODDOOSI, MAHDIEH, & HEIDARI, FATEMEH. (2023). Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(4), 478-485. SID. https://sid.ir/paper/1085317/en

    Vancouver: Copy

    MOSLEHI AZAM, KOMEILI MOVAHHED TAHEREH, Ahmadian Mostafa, GHODDOOSI MAHDIEH, HEIDARI FATEMEH. Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(4):478-485. Available from: https://sid.ir/paper/1085317/en

    IEEE: Copy

    AZAM MOSLEHI, TAHEREH KOMEILI MOVAHHED, Mostafa Ahmadian, MAHDIEH GHODDOOSI, and FATEMEH HEIDARI, “Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 4, pp. 478–485, 2023, [Online]. Available: https://sid.ir/paper/1085317/en

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