مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Irradiation and conditioned media from human umbilical cord stem cells suppress epithelial-mesenchymal transition biomarkers in breast cancer cells

Pages

  486-491

Abstract

 Objective(s): Breast cancer cells developing radioresistance during radiation may result in cancer recurrence and poor survival. One of the main reasons for this problem is the changes in the regulation of genes that have a key role in the epithelial-mesenchymal transition (EMT). Utilizing Mesenchymal stem cells can be an effective approach to overcome therapeutic resistance. In this study, we investigated the possibility of combining mesenchymal medium with cancer cell medium in sensitizing Breast carcinoma cells to radiation. Materials and Methods: In this experimental study, the cells were irradiated at a dose of 4 Gy alone and in combination with stem cells and cancer cells media. Apoptosis, cell cycle, Western blotting, and real-time PCR assays evaluated the therapeutic effects. Results: We found that the CSCM could decrease the expression of several EMT markers (CD133, CD44, Vimentin, Nanog, Snail, and Twist), resulting in increased cell distribution in the G1 and G2/M phases, apoptosis rate, and protein levels of p-Chk2 and cyclin D1,furthermore, it exhibits synergetic effects with radiation treatment in vitro. Conclusion: These findings show that CSCM inhibits the expansion of breast cancer cells and makes them more susceptible to Radiotherapy, offering a unique approach to treating breast cancer by overcoming radioresistance.

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    APA: Copy

    Ghanbarnasab Behbahani, Rahil, Danyaei, Amir, Shogi, Hamed, Tahmasbi, Mohammad Javad, SAKI, GHASEM, & NEISI, NILOOFAR. (2023). Irradiation and conditioned media from human umbilical cord stem cells suppress epithelial-mesenchymal transition biomarkers in breast cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(4), 486-491. SID. https://sid.ir/paper/1085321/en

    Vancouver: Copy

    Ghanbarnasab Behbahani Rahil, Danyaei Amir, Shogi Hamed, Tahmasbi Mohammad Javad, SAKI GHASEM, NEISI NILOOFAR. Irradiation and conditioned media from human umbilical cord stem cells suppress epithelial-mesenchymal transition biomarkers in breast cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(4):486-491. Available from: https://sid.ir/paper/1085321/en

    IEEE: Copy

    Rahil Ghanbarnasab Behbahani, Amir Danyaei, Hamed Shogi, Mohammad Javad Tahmasbi, GHASEM SAKI, and NILOOFAR NEISI, “Irradiation and conditioned media from human umbilical cord stem cells suppress epithelial-mesenchymal transition biomarkers in breast cancer cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 4, pp. 486–491, 2023, [Online]. Available: https://sid.ir/paper/1085321/en

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