Preparation of Efficient Kit for the Semi-Quantitative Determination of Sarcosine as a cancer marker by Grafting Molecularly Imprinted-Stationary on Glass Plate

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Farhad Gholami Nahid; Hashemi Moghaddam Hamid; Shaabanzadeh Masoud; Zavareh Saeed

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Journal Paper

Paper Information

Journal: Journal of Chemical Health Risks Year:621 | Volume: | Issue: Page(s): 259-266

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Title

Preparation of Efficient Kit for the Semi-Quantitative Determination of Sarcosine as a cancer marker by Grafting Molecularly Imprinted-Stationary on Glass Plate

Author(s)

Farhad Gholami Nahid | Hashemi Moghaddam Hamid | Shaabanzadeh Masoud | Zavareh Saeed | Issue Writer Certificate

Keywords

Imprinted polymerQ4

SarcosineQ4

KitQ4

GraftingQ4

Abstract

This paper presents a novel, rapid, and simple method for the determination of Sarcosine. The surface of a glass plate was modified with 3-(methacryloxy)propyltrimethoxysilane. Then, a Sarcosine-Imprinted polymer was grafted on the glass plate by copolymerization of the vinyl end groups with a functional monomer and a cross-linking agent. The synthesized polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. In the subsequent step, the determination of Sarcosine was conducted using the synthesized Kit in optimized conditions. The synthesized grafted plate was able to absorb Sarcosine selectively in the presence of other amino acids, showing that the proposed method enabled the rapid determination of Sarcosine.

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