The Study of the Effect of Biocanin A on Serum Levels of Tumor Necrosis Factor Alpha, Interferon Gamma and Malondialdehyde and Glutathione Levels in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAHERI FATEMEH; SALEMI ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Complementary Medicine Journal Year:2023 | Volume:13 | Issue:2 (47) Page(s): 1-13

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

The Study of the Effect of Biocanin A on Serum Levels of Tumor Necrosis Factor Alpha, Interferon Gamma and Malondialdehyde and Glutathione Levels in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats

Author(s)

TAHERI FATEMEH | SALEMI ZAHRA | Issue Writer Certificate

Keywords

T1DM

Biochanin A

TNF-a

IFN-y

Oxidative Stress

Abstract

Introduction: BiochaninA (BCA) is of interest due to its antioxidant and anti-inflammatory effects. Oxidative Stress and inflammation are key pathways in the development and progression of T1DM. The aim of this study is to determine the effect of biochaninA on the serum levels ofTNF-a, IFN-y, as well as the levels of GSH and MDA in the pancreas of rats infected with T1DM with streptozotocin. Methods: 28 male Wistar rats were randomly divided into 4groups of 7each. A healthy control group received DMSO, the solvent of biochaninA. The rest of them were subjected to peritoneal-injection of streptozocin at the rate of 55mg/kg. One group was selected as a diabetic control(the second group)that only received DMSO, and the other two groups were treated with biochaninA at the rate of 10mg/Kg(the third group)and 15mg/Kg(the fourth group)for 6weeks. At the end, blood was collected from the heart and the parameters of TNF-a, IFN-y and FBS were measured in the serum. Then GSH and MDA factors were measured in the homogenized pancreatic tissue. Results: The reduction of blood glucose and MDA was significant in treatment groups. GSH increased significantly with treatment. The reduction of TNF-a was significant only in the fourth group, but the reduction of IFN-y wasn't significant in any treatment group(P<0. 05). Conclusions: BiochaninA treatment is effective in controlling hyperglycemia. By increasing the level of GSH and decreasing MDA, this combination is important in improving the redox conditions in the pancreas, and by reducing the serum level of TNF-a, it improves the inflammatory conditions caused by diabetes and helps to reduce complications. No significant difference was observed between treatment doses.

Cites

No record.

References

Cite

APA: Copy

TAHERI, FATEMEH, & SALEMI, ZAHRA. (2023). The Study of the Effect of Biocanin A on Serum Levels of Tumor Necrosis Factor Alpha, Interferon Gamma and Malondialdehyde and Glutathione Levels in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 13(2 (47) ), 1-13. SID. https://sid.ir/paper/1087792/en

Vancouver: Copy

TAHERI FATEMEH, SALEMI ZAHRA. The Study of the Effect of Biocanin A on Serum Levels of Tumor Necrosis Factor Alpha, Interferon Gamma and Malondialdehyde and Glutathione Levels in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2023;13(2 (47) ):1-13. Available from: https://sid.ir/paper/1087792/en

IEEE: Copy

FATEMEH TAHERI, and ZAHRA SALEMI, “The Study of the Effect of Biocanin A on Serum Levels of Tumor Necrosis Factor Alpha, Interferon Gamma and Malondialdehyde and Glutathione Levels in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 13, no. 2 (47) , pp. 1–13, 2023, [Online]. Available: https://sid.ir/paper/1087792/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops